文章摘要
汤奋扬,霍〓翔,李〓亮,祖荣强,许〓可,祁〓贤,吴〓斌,嵇〓红,朱凤才,羊海涛.甲型H1N1流感重症病例的危险因素[J].南京医科大学学报,2010,(9):1262~1265
甲型H1N1流感重症病例的危险因素
Risk factors for severe cases of influenza A H1N1
投稿时间:2010-04-13  
DOI:10.7655
中文关键词: 甲型H1N1流感  重症病例  危险因素
英文关键词: infulenze A(H1N1)  severe cases  risk factors
基金项目:
作者单位
汤奋扬 江苏省疾病预防控制中心,江苏 南京〓210009 
霍〓翔 江苏省疾病预防控制中心,江苏 南京〓210009 
李〓亮 江苏省疾病预防控制中心,江苏 南京〓210009 
祖荣强 江苏省疾病预防控制中心,江苏 南京〓210009 
许〓可 江苏省疾病预防控制中心,江苏 南京〓210009 
祁〓贤 江苏省疾病预防控制中心,江苏 南京〓210009 
吴〓斌 江苏省疾病预防控制中心,江苏 南京〓210009 
嵇〓红 江苏省疾病预防控制中心,江苏 南京〓210009 
朱凤才 江苏省疾病预防控制中心,江苏 南京〓210009 
羊海涛 江苏省疾病预防控制中心,江苏 南京〓210009 
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中文摘要:
      目的:分析甲型H1N1流感患者发生重症临床表现的危险因素?方法:调查江苏省2009年6~12月间甲型H1N1流感确诊病例,利用统一设计的调查表收集信息,应用SAS 9.1.3软件进行单因素和多因素非条件Logistic回归分析重症危险因素和风险比值比(OR值)?结果:单因素Logistic回归分析显示,年龄?发病与首次就诊时间间隔?体重指数(BMI)?妊娠和慢性基础性疾病史为导致重症的影响因素(P < 0.01)?多因素Logistic回归分析显示,年龄?发病与首次就诊时间间隔?BMI和慢性基础性疾病史进入了最终模型(P < 0.05),其中慢性基础性疾病史对模型贡献最大(标准化回归系数β=0.72),其他依次为年龄(β=0.43)?BMI(β=0.35)和发病与首次就诊时间间隔(β=0.25)?因素合并分析显示,发病风险随着危险因素数量的增加而增加,存在剂量效应关系(P < 0.01)?结论:有慢性基础性疾病史?5岁以下儿童和年龄较大者?超重或肥胖者为甲型H1N1流感重症高危人群,感染甲型H1N1流感应尽量早期就诊,减少重症情况的发生?
英文摘要:
      Objective:To evaluate the risk factors for severe cases of influenza A H1N1. Methods:The confirmed cases of influenza A H1N1 during June to December 2009 in Jiangsu province were investigated using unified designed questionnaires. Univariate and multivariate non-conditional logistic regression were employed to analyze the risk factors and odds ratio(OR)with SAS 9.1.3. Results:Age,interval between incidence and first-visit,BMI,pregnant and chronic comorbid illness were identified as the risk factors of severe cases in univariate logistic regression models. And age,interval between incidence and first-visit,BMI and chronic comorbid illness got into the final multivariate logistic model. Among which,the contribution of chronic comorbid illness to the model was greatest(β=0.72),followed with age(β=0.43),BMI(β=0.35)and interval between incidence and first-visit(β=0.25). Joint effect analysis indicated a dose-response relationship between the increased risk and the amount of risk factors. Conclusion:Individuals with risk factors for severe cases of infulenza A H1N1 should receive earlytreatment.
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