文章摘要
马坤芳,王德旺,任 勇.β-环糊精选择性提取虎杖化学成分的研究[J].南京医科大学学报,2010,(11):1546~1550
β-环糊精选择性提取虎杖化学成分的研究
Study on selective abstraction of chemical constituents from Polygonum cuspidatum with β-cyclodextrin
投稿时间:2010-05-22  
DOI:10.7655
中文关键词: 环糊精  虎杖  化学成分  选择性提取
英文关键词: cyclodextrins  Polygonum cuspidatum  chemical constituents  selective extraction
基金项目:
作者单位
马坤芳 南京医科大学药学院,江苏 南京 210029 
王德旺 南京医科大学第一附属医院药剂科,江苏 南京 210029 
任 勇 南京师范大学新药研究中心,江苏 南京 210097 
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中文摘要:
      目的:研究β-环糊精选择性提取虎杖中化学成分的可行性?方法:利用水溶液中β-环糊精与客体分子包合法选择提取虎杖中的化学成分,RP-HPLC梯度分析脱包物成分?结果:HPLC图谱显示选择提取部位有6个主成分峰,半制备液相色谱及重结晶分离出6个化合物;经波谱法确证其中5个化合物为大黄素?大黄素甲醚?白藜芦醇?大黄素-8-O-β-D-葡萄糖苷和白藜芦醇苷?结论:β-环糊精可选择性提取纯化虎杖中的化学成分,为中草药化学成分的提取分离给出一种新的研究方法?
英文摘要:
      Objective:To study the feasibility of selective extraction of chemical constituents from Polygonum cuspidatum with β-cyclodextrin. Methods:Chemical constituents of Polygonum cuspidatum were selectively extracted by crystallization of β-cyclodextrin inclusion complex in aqueous solution. Results:Six constituents in complex were shown by HPLC spectroscopy. Six compounds were isolated by semi-preparative reversed phase liquid chromatography and recrystallized. Five of the six compounds were identified:emodin, physcion, resveratrol, emodin-8-O-β-D-glucopyranoside and polydation. Conclusion:Chemical constituents of Polygonum cuspidatum could be selectively extracted with β-cyclodextrin. This method is a new way of extraction of chemical constituents from Chinese Herbal Medical.
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