文章摘要
唐 伟,李剑波,段 宇,刘 超,杨 涛.2型糖尿病合并原发性高血压患者临床特征分析[J].南京医科大学学报,2010,(11):1633~1635
2型糖尿病合并原发性高血压患者临床特征分析
Analysis on the clinical features of the patients with type 2 diabetes and primary hypertension
投稿时间:2010-04-16  
DOI:10.7655
中文关键词: 2型糖尿病  原发性高血压  脂代谢紊乱  高尿酸血症
英文关键词: type 2 diabetes mellitus  hypertention  dyslipidemia  hyperuricemia
基金项目:
作者单位
唐 伟 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
李剑波 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
段 宇 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
刘 超 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
杨 涛 南京医科大学第一附属医院内分泌科,江苏 南京 210029 
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中文摘要:
      目的: 观察2型糖尿病合并原发性高血压患者和单纯2型糖尿病患者的平均血糖?血脂?血尿酸等指标以及心脑血管并发症及微量白蛋白尿发病情况,分析糖尿病伴原发性高血压的临床特征及其危害性?方法:2型糖尿病患者752例,分为合并原发性高血压组324例,血压正常组428例?分别观察患者性别?年龄?病程?体重指数?糖化血红蛋白?血脂?血尿酸?心脑血管并发症及尿微量白蛋白排泄率并加以分析?结果:2型糖尿病合并原发性高血压患者占43.1%;两组间性别?年龄?病程?糖化血红蛋白差异无统计学意义(P > 0.05),原发性高血压组患者体质指数[(24.9±3.7) kg/m2]?总胆固醇[(4.9±1.3) mmol/L]?低密度脂蛋白胆固醇[(3.1±1.2) mmol/L]?甘油三酯[(2.5±3.0) mmol/L]?血尿酸[(325.2±122.9) μmol/L]水平高于血压正常的糖尿病患者,心脑血管并发症发生率(15.1%)?尿微量白蛋白排泄率[(47.7±91.4) mg/g]及阳性率(24.3%)显著高于血压正常组患者(P < 0.01及P < 0.05)?结论:2型糖尿病患者中,伴原发性高血压者较非高血压人群具有更高的体质指数?总胆固醇?低密度脂蛋白胆固醇?甘油三酯和血尿酸水平,发生心脑血管病变和肾脏损害的几率升高?2型糖尿病患者需控制体重,纠正高血糖?血脂代谢紊乱和高尿酸血症,高度重视原发性高血压的防治,使代谢性指标和血压全面达标,从而更为有效地预防糖尿病心脑血管及肾脏并发症的发生?
英文摘要:
      Objective: To observe average blood sugar,lipid profiles,serum uric acid level,cardio-cerebrovascular diseases and urinary albumin excretion incidence in type 2 diabetic patients with or without hypertension. Methods:Seven hundred and fifty five patients with type 2 diabetes were recruited and divided into normal blood pressure group(n=428)and hypertension group(n=324). Age,body mass index(BMI),HbA1c,total cholesterol(TC),triglyceride(TG),HDL-C,LDL-C,serum uric acid(SUA),urinary albumin excretion(UAE)rate were detected,the incidence of cardiovascular and cerebrovascular diseases were calculated. Results:Subjects with type 2 diabetes and primary hypertension accounted for 43.1% in this study population;age,gender,HbA1c and duration of diabetes in hypertension group were not different to those in normal blood pressure group(P > 0.05). BMI[(24.9±3.7) kg/m2],TC[(4.9±1.3) mmol/L],LDL-C[(3.1±1.2) mmol/L],TG[(2.5±3.0) mmol/L],SUA[(325.2±122.9) μmol/L] in hypertension group were higher than those in normal blood pressure group. The UAE rate[(47.7±91.4) mg/g] and positive ratio of UAE(24.3%),the cardiovascular and cerebrovascular diseases rate(15.1%)in hypertension group were higher significantly(P < 0.05,P < 0.01,respectively). Conclusion:Patients with type 2 diabetes mellitus and hypertension are prone to suffer from dyslipidemia,hyperuricemia,cadio-celebrovascular diseases and nephropathy than patients without hypertension.More attention should be paid to improve blood glucose,lipid profiles,uric acid and blood pressure control and prevent diabetic cardia-cerebrovascular and renal complications.
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