文章摘要
岳 聪,王苗苗,王美林,王 炜,张正东,韩素萍.mir-146a基因多态与卵巢癌易感性的关系:病例-对照研究[J].南京医科大学学报,2011,(4):517~521
mir-146a基因多态与卵巢癌易感性的关系:病例-对照研究
mir-146a gene polymorphism and the risk of ovarian cancer:a case-control study
投稿时间:2010-09-15  
DOI:10.7655
中文关键词: mir-146a  卵巢癌  基因多态  分子流行病学
英文关键词: mir-146a  ovarian cancer  polymorphism  molecular epidemiology
基金项目:江苏省自然科学基金(BK2009418)
作者单位
岳 聪 南京医科大学第一附属医院妇产科,江苏 南京 210029 
王苗苗 南京医科大学公共卫生学院分子遗传毒理学实验室,江苏 南京210029 
王美林 南京医科大学公共卫生学院分子遗传毒理学实验室,江苏 南京210029 
王 炜 南京医科大学公共卫生学院分子遗传毒理学实验室,江苏 南京210029 
张正东 南京医科大学公共卫生学院分子遗传毒理学实验室,江苏 南京210029 
韩素萍 南京医科大学第一附属医院妇产科,江苏 南京 210029 
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中文摘要:
      目的:探讨mir-146a g>c(rs2910164)基因多态与江苏人群卵巢癌遗传易感性的关系?方法:采用聚合酶链反应-限制性片段长度多态性(pcr-rflp)技术,检测131例卵巢癌患者和227例年龄相匹配非肿瘤者mir-146a g>c多态的频率和分布,比较不同基因型携带者患卵巢癌的危险性;通过分层分析探讨年龄?初潮年龄?产次?流产数及绝经史对罹患卵巢癌的影响?结果:病例组和对照组间mir-146a g>c各基因型频率差异无统计学意义(p > 0.05),分层分析结果显示,在不同年龄?初潮年龄?产次?流产数及是否绝经特征分层中,病例组与对照组各基因型频率差异仍无统计学意义?结论:本研究未发现mir-146a g>c基因多态与罹患卵巢癌危险性存在统计学关联?
英文摘要:
      objective:to investigate the association between the mir-146a gene polymorphism(rs2910164) and the susceptibility of ovarian cancer in jiangsu province. methods:in a hospital-based case-control study of 131 patients with newly diagnosed ovarian cancer and 221 cancer-free controls frequency-matched by age,the polymorphism of mir-146a gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism(pcr-rflp). the risk of ovarian cancer was compared between carriers of different genotypes. age,age at menarche,parity,number of abortions and menopausal status of cases were further stratified to investigate their effects on the risk of ovarian cancer. results:no significant difference was found between the mir-146a polymorphism of patients and of controls. conclusion:our results showed that the mir-146a g>c polymorphism may not contribute to the risk of ovarian cancer in jiangsu province.
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