文章摘要
朱 军,蒯正平,严建军,王泽穆,唐建金,杨志健,王连生.MCP-1/CCR2基因多态性与冠状动脉疾病关联性的Meta分析[J].南京医科大学学报,2011,(6):827~833
MCP-1/CCR2基因多态性与冠状动脉疾病关联性的Meta分析
Meta-analysis on the association between MCP-1/CCR2 genes polymorphisms and coronary artery disease
投稿时间:2010-11-28  
DOI:10.7655
中文关键词: 单核细胞趋化蛋白-1/趋化因子受体2  基因多态性  冠状动脉疾病  Meta分析
英文关键词: MCP-1/CCR2  polymorphism  coronary artery disease  Meta-analysis
基金项目:国家自然科学基金资助(30871078)
作者单位
朱 军 南京医科大学第一附属医院心内科,江苏 南京 210029 
蒯正平 南京医科大学第一附属医院心内科,江苏 南京 210029 
严建军 南京医科大学第一附属医院心内科,江苏 南京 210029 
王泽穆 南京医科大学第一附属医院心内科,江苏 南京 210029 
唐建金 南京医科大学第一附属医院心内科,江苏 南京 210029 
杨志健 南京医科大学第一附属医院心内科,江苏 南京 210029 
王连生 南京医科大学第一附属医院心内科,江苏 南京 210029 
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中文摘要:
      目的:采用Meta分析探讨单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)基因的G2518A位点及趋化因子受体2(CC chemokine receptor 2,CCR2)基因的G190A位点多态性与冠状动脉疾病(coronary artery disease,CAD)的关联性?方法:通过PubMed,EMbase,CNKI及CBM等数据库搜索关于MCP-1/CCR2基因多态性与CAD关联性的文章?结果:符合纳入标准的共有21篇文献,MCP-1基因的G2518A位点和CCR2基因的G190A位点分别有6 835例CAD患者?11 142例正常对照受试者,以及2 801例CAD患者?5 789例正常对照受试者入选?综合数据表明MCP-1基因的G2518A位点和CCR2基因G190A位点多态性与CAD的发生存在关联[G2518A(P = 0.04),G190A(P = 0.005)]?根据分层分析观察到MCP-1基因的G2518A位点在非亚洲人群中与CAD存在关联性(P = 0.04),而在亚洲人群中与CAD不具有统计学意义(P > 0.05)?结论:MCP-1基因的G2518A位点及CCR2基因的G190A位点多态性与CAD的发生具有统计学意义?
英文摘要:
      Objective:To assess the association of monocyte chemotactic protein-1(MCP-1)gene G2518A and CC chemokine receptor 2(CCR2) gene G190A polymorphisms with coronary artery disease(CAD). Methods:Databases, including PubMed, EMbase, CNKI and CBM, were searched to get the association studies on MCP-1/CCR2,RANTES/CCR5 genes polymorphisms and CAD. Results:A total of 21 case-control studies were identified. The Meta-analysis included 6 835(MCP-1-G2518A) CAD case and 11 142 controls,2 801 CAD cases and 5 789 controls(CCR2-G190A),respectively. MCP-1 gene G2518A polymorphism was significantly associated with CAD(P = 0.04). The CCR2 gene G190A polymorphism was also significantly associated with the presence of CAD(P = 0.005). In stratified analysis by race, the MCP-1 gene G2518A polymorphism was significantly associated with the presence of CAD in non-Asian(P = 0.04), while not in Asian(P > 0.05). Conclusion:Our results showed that the MCP-1 gene G2518A and CCR2 gene G190A polymorphisms were associated with an increased risk of CAD.
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