文章摘要
陆卫平,刘 超.2型糖尿病并非酒精性脂肪性肝病患者血清游离脂肪酸和细胞角蛋白18的表达[J].南京医科大学学报,2011,(6):860~863
2型糖尿病并非酒精性脂肪性肝病患者血清游离脂肪酸和细胞角蛋白18的表达
Increased expression of blood serum free fatty acids and cytokeratin 18 in patients with type 2 diabetes with non alcoholic fatty liver disease
投稿时间:2010-11-16  
DOI:10.7655
中文关键词: 糖尿病,2型  非酒精性脂肪性肝病  胰岛素抵抗  游离脂肪酸  细胞角蛋白18  凋亡
英文关键词: diabetes, type 2  NAFLD  insulin resistance  FFA  CK18  apoptosis
基金项目:江苏省医学重点人才基金资助(RC2002043)
作者单位
陆卫平 南京医科大学第一附属医院内分泌科 ,江苏 南京 210029 
刘 超 南京医科大学第一附属医院内分泌科 ,江苏 南京 210029 
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中文摘要:
      目的:探讨2型糖尿病(T2DM)并非酒精性脂肪性肝病(NAFLD)患者血清游离脂肪酸(FFA)和细胞角蛋白18(CK 18)的表达及其影响?方法:T2DM患者40例,T2DM并NAFLD患者40例,健康对照组20例?体格检查,测定静脉血空腹血糖(FPG)?胆固醇(TC)?甘油三酯(TG)? 丙氨酸转氨酶(ALT)?天门冬氨酸转氨酶(AST)? γ-谷氨酰转肽酶(GGT)?糖化血红蛋白(HbA1c)?胰岛素(FINS)以及血清FFA和CK18,并行肝脏B超检查?结果:① T2DM组的体质指数(BMI)?FPG?FINS?A1C水平和胰岛素抵抗指数(HOMA-IR)显著高于正常对照组,差异有统计学意义;TC?TG?ALT?AST?GGT水平差异无统计学意义?T2DM并NAFLD患者的BMI?FPG?FINS?TC?TG?ALT?AST?GGT水平和HOMA-IR均显著高于T2DM患者,差异有统计学意义(P < 0.001);② T2DM组与正常对照组相比,FFA水平明显增高,差异有统计学意义,CK18水平差异无统计学意义?而T2DM并NAFLD组FFA和CK18水平均高于正常对照组和T2DM组,差异有统计学意义(P < 0.001)?结论:与T2DM相比,T2DM并NAFLD患者胰岛素抵抗?代谢紊乱更加显著,肝细胞的凋亡增加,对于进一步研究T2DM并NAFLD的发病机制具有重要的意义?
英文摘要:
      Objective: To explore the expression of blood serum free fatty acid (FFA) and cytokeratin 18 (CK18) and their impact on patients with type 2 diabetes mellitus with non alcoholic fatty liver disease (NAFLD). Methods: Forty patients with type 2 diabetes, 40 cases with type 2 diabetes with alcoholic fatty liver disease, 20 cases of healthy controls were enrolled. Fasting blood glucose (FPG), cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl (GGT), glycated hemoglobin (HbA1c), insulin (FINS), FFAa and CK18 were detected, and liver B-ultrasound was performed. Results: ① BMI, FPG, FINS, A1C levels and HOMA-IR were significantly higher in group of type 2 diabetes than that of the normal control group; CH, TG, ALT, AST, GGT levels were not significantly different. BMI, FPG, FINS, CH, TG, ALT, AST, GGT levels and HOMA-IR were significantly higher in group of type 2 diabetes with NAFLD than that of type 2 diabetes group (P <0.001); ② Compared with normal control group, FFA levels were significantly increased in group of type 2 diabetes, but CK18 levels were not significantly different. In group of type 2 diabetes with NAFLD, CK18 and FFA levels were higher than normal control group as well as type 2 diabetes group(P < 0.001). Conclusion: Compared with type 2 diabetes patients, insulin resistance, metabolic disorders were more significant and apoptosis of liver cells increased in patients with type 2 diabetes with NAFLD. Further study on pathogenesis of type 2 diabetes with NAFLD should be performed.
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