食管鳞状细胞癌中CD24的表达及其临床意义
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The expression and clinical significance of CD24 in human esophageal squamous cell carcinoma
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    摘要:

    目的:探讨CD24表达与食管鳞癌发生-发展-病理分级-临床分期-浸润程度和淋巴结转移的关系-方法:采用免疫组织化学SP法检测63例手术切除并经病理检查证实的食管鳞癌标本中CD24的表达,CD24表达量以阳性率表示-结果:食管癌组织中CD24在细胞膜-细胞核和细胞浆中均有表达, 阳性率分别为80.95%(51/63)-88.88%(56/63)-85.71%(54/63);癌旁组织中CD24仅在细胞膜-细胞核表达,阳性率分别为55.56%(35/63)-50.79%(32/63)-CD24在食管癌组织中的表达水平明显高于癌旁组织 (P < 0.05) -并且随着肿瘤浸润程度的增加-淋巴结转移数目的增多及TNM分期的升高,CD24 细胞膜-细胞核和细胞浆表达的阳性率均随之增高,各组间比较差异有统计学意义(P < 0.05)-而与患者年龄-性别-肿瘤位置-肿瘤分化等因素无相关性(P > 0.05)-结论:CD24表达与食管鳞癌细胞的浸润程度-淋巴结转移数目-有无远处转移及TNM分期呈正相关(P <0.05)-CD24在肿瘤的发生-发展中起重要作用,且有可能成为判断食管鳞癌患者预后的一个新指标-

    Abstract:

    Objective:To investigate the expression and clinical significance of CD24 in human esophageal squamous cell carcinoma(ESCC). Methods:CD24 expression of 63 esophageal squamous cell carcinomas was analyzed by SP immunohistochemistry,and the expression level of CD24 was calculated by the positive cells ratio. Results:CD24 expression was observed in cytomembrane,cytoblast and cytoplasm in esophageal squamous cell carcinoma tissues. The positive rates were 80.95%(51/63),88.88%(56/63)and 85.71%(54/63),respectively,which were obviously higher than 55.56%(35/63),50.79%(32/63) and 0 in the normal esophageal tissues. The expression of CD24 was increasing with the deep of invasion, the increasing number of regional lymph nodes, the distant metastasis and the clinical stage of tumor. The differences among each groups were statistically significant(all P < 0.05). Conclusion:The expression of CD24 has a positive correlation with the depth of invasion, the regional lymph nodes, the distant metastasis and the TNM stage of esophageal squamous cell carcinoma (P < 0.05). The expression of CD24 may play a significant role in the development of the esophageal squamous cell carcinoma and be a new independent prognostic marker in tumor progression of this disease.

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詹必成,陈 亮,朱 全,张石江.食管鳞状细胞癌中CD24的表达及其临床意义[J].南京医科大学学报(自然科学版),2011,(6):872-876

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  • 收稿日期:2010-11-08
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