文章摘要
杨书云,朱兴华,陈亚丽,何 松,张建兵.120例乳腺癌组织中HDAC-1蛋白表达的临床病理[J].南京医科大学学报,2011,(6):877~881
120例乳腺癌组织中HDAC-1蛋白表达的临床病理
HDAC-1 protein expression in one hundred and twenty cases of breast cancer
投稿时间:2010-12-16  
DOI:10.7655
中文关键词: 乳腺癌  组蛋白去乙酰化酶-1  免疫组织化学  临床病理特征
英文关键词: breast cancer  histone deacetylase 1(HDAC-1)  immunohistochemistry  clinical and pathological features
基金项目:南通市科技局社会发展计划资助(S2007012)
作者单位
杨书云 南通市肿瘤医院病理科,江苏 南通 226361 
朱兴华 南通市肿瘤医院病理科,江苏 南通 226361 
陈亚丽 南通市肿瘤医院病理科,江苏 南通 226361 
何 松 南通市肿瘤医院病理科,江苏 南通 226361 
张建兵 南通市肿瘤医院病理科,江苏 南通 226361 
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中文摘要:
      目的:探讨乳腺癌组织中组蛋白去乙酰化酶-1(histone deacetylase 1,HDAC-1)的表达意义及其与临床病理特征之间存在的相关性?方法:应用免疫组织化学Envision二步法检测120例乳腺癌组织和对照组20例乳腺增生症乳腺组织中HDAC-1蛋白的表达,分析其与临床特征,以及常规检测指标雌激素受体(ER)?孕激素受体(PR)?人表皮生长因子受体-2(human epidermalgrowth factor receptor-2,HER-2)之间的关系?结果:120例乳腺浸润性导管癌中,HDAC-1高表达43例(35.83%),对照组20例乳腺增生病变中HDAC-1低表达或不表达,两者之间表达差异有统计学意义?乳腺癌中HDAC-1高表达与年龄?临床分期?HER-2表达均有显著相关性(P < 0.01),即与患者年龄 > 50岁组(49.50%)和临床分期为Ⅲ~Ⅳ期组(64.28%)及HER-2(55.26%)的表达呈正相关;与肿瘤的大小?组织学分级?淋巴结转移的有无?以及癌组织间及癌旁组织中有无淋巴细胞的浸润无相关(P > 0.05),与ER(33.89%)?PR(39.28%)的表达无相关(P > 0.05)?结论:HDAC-1在乳腺癌和良性增生性病变诊断及鉴别诊断中有参考意义;HDAC-1蛋白在乳腺癌的发生发展中起重要作用;HDAC-1抑制剂有望成为乳腺癌治疗的新靶向药物?
英文摘要:
      Objective:To investigate the correlation between histone deacetylase 1(HDAC-1) expression and clinical pathological significance. Methods:HDAC-1 protein expression in 120 cases of breast cancers and a control group of 20 cases of breast hyperplasia in breast tissue were examined by immunohistochemical, and the relationships between HDAC-1 protein and clinical features and conventional detection index of ER, PR, HER-2 were analyzed. Results:Among 120 patients with breast cancer, HDAC-1 was high expressed in 43 cases(35.83%), but HDAC-1 was low expressed or not in control group, the difference was significant. HDAC-1 in breast cancers with high expression was significantly correlated with age, clinical stage, HER-2, expression(all P < 0.05): patients who were older than 50 years(49.50%), in clinical period of stage Ⅲ ~ Ⅳ(64.28%), or HER-2(55.26%) was positive correlation with HDAC-1 high expression, but HDAC-1 expression was negatively correlated with tumor size, histological grade, with or without lymph node metastasis, and cancer tissues and adjacent tissues without infiltration of lymphocytes, and ER(33.89%) or PR(39.28%) expression(P > 0.05). Conclusion: HDAC1 protein plays an important role in the development of breast cancer, and HDAC-1 inhibitor is expected to become a new targeting drug for breast cancer treatment.
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