文章摘要
黄 霞,赵德育,姜艳荷,王 全,刘 峰.南京地区儿童呼吸道变应性疾病常见吸入性变应原临床分析[J].南京医科大学学报,2011,(6):907~911
南京地区儿童呼吸道变应性疾病常见吸入性变应原临床分析
Clinical analysis of common inhalant allergens in respiratory alIergic diseases of children in Nanjing
投稿时间:2010-11-27  
DOI:10.7655
中文关键词: 皮肤点刺试验  哮喘  变应性鼻炎  变应原  尘螨
英文关键词: skin prick test  asthma  allergic rhinitis  allergen  dust mite
基金项目:南京市2009年第一批科技发展项目(200901064)
作者单位
黄 霞 南京医科大学附属南京儿童医院呼吸内科,江苏 南京 210008 
赵德育 南京医科大学附属南京儿童医院呼吸内科,江苏 南京 210008 
姜艳荷 南京医科大学附属南京儿童医院呼吸内科,江苏 南京 210008 
王 全 南京医科大学附属南京儿童医院呼吸内科,江苏 南京 210008 
刘 峰 南京医科大学附属南京儿童医院呼吸内科,江苏 南京 210008 
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中文摘要:
      目的:了解南京地区儿童呼吸道变应性疾病主要吸入性变应原,为呼吸道变应性疾病的防治提供依据?方法:选择2009年8月~2010年7月就诊的南京地区1~12岁变应性鼻炎和(或)支气管哮喘患儿4 355例,应用13种吸入性变应原对其进行皮肤点刺试验(skin prick test,SPT),分析各种变应原阳性率?阳性反应程度及阳性种类数与性别及年龄相关性?结果:在4 355例患儿中,2 618例(60.1%)具有特应性(SPT≥1个变应原阳性),屋尘螨和粉尘螨阳性率最高,分别为52.0%和50.9%,其阳性程度亦居首位?随年龄增长,变应原阳性率?阳性程度及阳性种类均增加,性别特应性差异更加明显(男女变应原阳性率分别为:幼年期40.9% vs 38.9%,P = 0.686;学龄前59.0% vs 55.8%,P = 0.100;学龄期76.2% vs 65.9%,P = 0.000)?结论:南京地区呼吸道变应性疾病患儿大都具有特应性,其中尘螨是主要吸入性变应原,随年龄增长,特应性程度增加,性别差异更显著?
英文摘要:
      Objective: To investigate the main inhalant allergens in children with respiratory allergic disease in Nanjing urban districts and provide evidence for prevention and treatment of patients with respiratory allergic diseases. Methods: All cases were collected from out-patient and in-patient department of the Nanjing Children’s Hospital Affiliated to Nanjing Medical University from June 1 st,2009 to July 31 th,2010. Four thousand three hundred and fifty-five children lived in Nanjing urban districts, aged from 1 to 12 years old with diagnoses of asthma and(or)allergic rhinitis were enrolled. All the patients underwent skin prick tests(SPT) with 13 standardized common inhalant allergens. The positive rates, grades and categories of allergens were analyzed. Results:①Of the 4 355 patients,2 618(60.1%)were atopic. Dermatophagoides pteronyssinus(D.p,52.0%) and Dermatophagus farinae(D.f,50.9%) were the most prevalent inhalant allergens.② As age growing, the positive rates, grades and categories of skin prick tests increased, and the preponderance of atopy in boys was more significant. Conclusion: D.p and D.f were the most prevalent inhalant allergens in respiratory allergic disease in Nanjing urban districts. With age growing, children, especially boys, with respiratory allergic disease are more sensitive to inhalant allergens.
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