文章摘要
郑 亮,夏加增,裴 雷,顾 琛,姚路斌,洪 波.胃癌患者血清IL-6?CRP水平的变化及其与肿瘤血管生成的关系[J].南京医科大学学报,2011,(7):1017~1020
胃癌患者血清IL-6?CRP水平的变化及其与肿瘤血管生成的关系
The changes of serum levels of IL-6 and CRP in patients with gastric carcinoma and the relationship with angiogenesis in neoplasms
投稿时间:2011-01-04  
DOI:10.7655
中文关键词: 胃癌  白细胞介素-6  C-反应蛋白  血管内皮生长因子  CD31  微血管密度
英文关键词: gastric carcinoma  interleukin-6  C-reactive protein  vascular endothelial growth factor  CD31  microvessel density
基金项目:南京医科大学科技发展基金重点项目(NJMU04)
作者单位
郑 亮 南京医科大学附属无锡第二人民医院普外科,江苏 无锡 214002 
夏加增 南京医科大学附属无锡第二人民医院普外科,江苏 无锡 214002 
裴 雷 南京医科大学附属无锡第二人民医院普外科,江苏 无锡 214002 
顾 琛 南京医科大学附属无锡第二人民医院普外科,江苏 无锡 214002 
姚路斌 南京医科大学附属无锡第二人民医院普外科,江苏 无锡 214002 
洪 波 南京医科大学附属无锡第二人民医院普外科,江苏 无锡 214002 
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中文摘要:
      目的:观察胃癌患者血清白细胞介素-6(IL-6)?C-反应蛋白(CRP)的水平变化,同时研究胃癌组织中血管内皮生长因子(VEGF)?CD31的表达及其与血清IL-6水平的关系?方法:应用酶联免疫吸附试验(ELISA)测定IL-6的水平,采用Beckman蛋白测定系统检测CRP,应用免疫组化技术检测VEGF?CD31在胃癌中的表达?结果:胃癌患者血清IL-6水平较对照组明显升高(P < 0.001),并与肿瘤病理分期有关,肿瘤切除后血清IL-6水平明显降低(P < 0.001);VEGF的阳性细胞百分数和CD31抗体标记的微血管密度(MVD)均随病理分期增高而升高,且均与血清IL-6水平呈正相关?结论:血清IL-6?VEGF?CD31的检测有助于胃癌的早期诊断与治疗,并提示病情及预后?
英文摘要:
      Objective:To study the changes of serum levels of interleukin-6(IL-6) and C-reactive protein(CRP) in patients with gastric carcinoma and the relationship of the expression of vascular endothelial growth factor(VEGF) and CD31 with the serum level of IL-6. Methods:IL-6 was evaluated by enzyme-linked immunosorbent test(ELISA). CRP was detected by Beckman albumen measuring system. The expression of VEGF and CD31 in gastric carcinoma tissues was detected by immunohistochemistry. Results:The serum level of IL-6 in patients with gastric carcinoma was significantly higher than controls(P < 0.001) and concerned with staging. After operation, the serum level of IL-6 decreased significantly(P < 0.001). The percentage of VEGF positive cells and the microvessel density(MVD) labeled by CD31 antibody gradually increased with the staging. They were all positively correlated with the serum level of IL-6. Conclusion:The detection of serum IL-6?VEGF and CD31 in gastric carcinoma patients is useful to early diagnosis, therapy and to anticipate the condition and prognosis.
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