文章摘要
华 烨,丁新生.中国汉族人群MTHFR C677T基因多态性与阿尔茨海默病发病风险的meta分析[J].南京医科大学学报,2011,(7):1040~1044
中国汉族人群MTHFR C677T基因多态性与阿尔茨海默病发病风险的meta分析
A meta-analysis on the association between the MTHFR gene C677T polymorphism and Alzheimer’s disease in Chinese population
投稿时间:2011-02-24  
DOI:10.7655
中文关键词: MTHFR基因  阿尔茨海默病  meta分析
英文关键词: MTHFR  Alzheimer’s disease  meta-analysis
基金项目:
作者单位
华 烨 南京医科大学附属无锡二院神经内科,江苏 无锡 214002 
丁新生 南京医科大学第一附属医院神经内科,江苏 南京 210029 
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中文摘要:
      目的:探索中国人群四氢叶酸还原酶(MTHFR)基因C677T多态性与阿尔茨海默病(AD)的关系?方法:对符合条件的研究进行meta分析,分别以1 048例AD患者和1 220例对照人群等位基因和基因型频率分布的OR值为统计量,采用固定或随机效应模型进行合并分析,并进行偏倚评估?结果:9篇文献符合条件纳入研究,入选文献无明显发表偏倚?数据合并结果显示:T等位基因?TT+TC基因型合并的OR值(95%CI)分别为1.21(1.07~1.37)和1.44(1.07~1.93)?结论:MTHFR C677T基因多态性与阿尔茨海默病发病具有相关性?
英文摘要:
      Objective:To investigate the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism and Alzheimer’s disease(AD). Method:A meta-analysis including 1 048 cases and 1 220 controls in eligible studies were performed. The odds ratio(OR) of genotype and allele frequencies were regarded as statistics value, a random-effect or fixed-effect model was used in the analysis, and publication bias was assessed. Results:Nine papers met the criterion and were included in the meta study, and no significant publication bias was showed. The OR(95%CI) values of T/C and(TT+TC)/CC were 1.21(1.07~1.37) and 1.44(1.07~1.93). Conclusion:The MTHFR C677T polymorphism is associated with AD.
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