153Gd衰减校正对门控心肌断层显像测定左室心功能参数的影响
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江苏省卫生厅2008年度“六大人才高峰”D类资助(2008073)


153Gd attenuation corrected 99mTc-MIBI gated myocardial perfusion single photon emission tomography for the assessment of left ventricular function
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    目的:探讨153Gd衰减校正(AC)处理对99mTc-甲氧基异丁基异腈(MIBI)门控心肌断层显像(G-SPECT)测定左室心功能参数的影响-方法:69例疑为冠心病患者,均行99mTc-MIBI静息G-SPECT,分别用AC和非衰减校正(NC)处理,测得舒张末期容量(EDV)-收缩末期容量(ESV)-左室射血分数(LVEF),所有患者在1~4周内行二维超声心动图(2-DE)检查测定LVEF,比较AC-NC和2-DE测得LVEF的相关性-结果:①NC和AC测得EDV-ESV分别为(79.6 ± 33.4)ml-(33.8 ± 29.9)ml和(87.4 ± 34.8)ml-(36.7 ± 31.9)ml,它们之间的相关性良好(rEDV=0.99,y = 1.04x + 4.73;rESV=0.99,y = 1.06x + 0.79;P均 < 0.01),但AC测得的EDV-ESV均> NC(P均 < 0.01);②NC和AC测得LVEF分别为(60.3 ± 9.2)%-(60.8 ± 9.9)%,它们之间的相关性良好(r = 0.98,y = 1.02x-1.04,P < 0.01),且两者间没有统计学差异(P > 0.05);③2-DE测得的LVEF为(54.6 ± 8.9)%,< NC-AC测得的LVEF(P均 < 0.01),但它们之间的相关性良好(rNC = 0.88,y = 0.91x + 10.81;rESV = 0.81,y = 0.87x + 13.10;P均 < 0.01)-结论:AC处理99mTc-MIBI G-SPECT测得的LVEF准确-可靠,和NC-2-DE测得的LVEF相关性良好-

    Abstract:

    Objective:To evaluate the attenuation corrected(AC) 99m Tc-MIBI gated myocardial perfusion single photon emission tomography (G-SPECT) for the assessment of left ventricular ejection fraction(LVEF). Methods:Total 69 patients probably with coronary artery disease were enrolled in this study. All of them underwent resting G-SPECT and two dimensional echocardiography (2-DE). Left ventricular ejection fraction (LVEF),left ventricular end-diastolic volume(EDV) and left ventricular end-systolic volume (ESV) were acquired from attenuation corrected and non-attenuation corrected (NC) 99mTc-MIBI G-SPECT and 2-DE. T test and correlation analysis were used to compared the parameter of heart function. Results:① EDV and ESV measured by AC and NC G-SPECT were (79.6 ± 33.4) ml and (87.4 ± 34.8) ml (P < 0.01),and (33.8 ± 29.9) ml and (36.7 ± 31.9) ml (P < 0.01). EDV and ESV measured by AC were positively correlated with EDV and ESV measured by NC (rEDV = 0.99,y = 1.04x + 4.73,P < 0.01;rESV = 0.99,y = 1.06x + 0.79,P < 0.01). ② LVEF determined by AC and NC G-SPECT were (60.3 ± 9.2)% and (60.8 ± 9.9)%. No statistical significance was observed between them. However,the positive correlation was found between them(r = 0.98,y = 1.02x-1.04,P < 0.01). ③ LVEF measured by 2-DE was(54.6 ± 8.9)%,which was markedly lower than them determined by AC and NC (P < 0.01). There were positive correlation between them (rNC = 0.88,y = 0.91x + 10.81,P < 0.01;rESV = 0.81,y = 0.87x + 13.10,P < 0.01). Conclusion:LVEF measured by AC G-SPECT,which is accurate and reliable,correlates well with LVEF determined by NC G-SPECT and 2-DE.

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冯建林,赵中强,袁冬兰,周艳丽,李殿富.153Gd衰减校正对门控心肌断层显像测定左室心功能参数的影响[J].南京医科大学学报(自然科学版),2011,(8):1216-1219

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  • 收稿日期:2011-03-17
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