Objective: To investigate the incidence and distribution of non-motor symptoms(NMS) in patients with newly diagnosed Parkinson’s disease(PD),and its relationship with clinical features and various scales. Methods: Total 61 PD patients without taking any drugs and 89 normal controls were collected in outpatient visits,and their clinic information and related scales were evaluated. Results: 96.7% PD patients with NMS commonly had decreased recent memory(62.3%,38 cases),decreased attention(57.4%,35 cases),constipation (49.2%,30 cases),and there were significant difference between PD group and normal group in those symptoms(P < 0.01). NMSQuest average score of the PD group (9.1 ± 5.2),moderate PD disease group (12.2 ± 4.6) and mild group (7.2 ± 3.7) were significantly higher than that of the control group (2.9 ± 2.5) (P < 0.01). NMSQuest was positively correlated with H-Y stage (rs = 0.3,P < 0.01),SDS (rs = 0.7,P < 0.01) and SAS (rs = 0.7,P < 0.01) respectively,and was negatively correlated with PDSS (rs = -0.6,P < 0.01), age,age at onset,gender,duration. UPDRS-Ⅲ score and MOCA were negatively correlated with NMSQuest. Conclusion: NMS in patients with newly diagnosed PD were complex and diverse,and patients with newly diagnosed PD had higher incidence rate than normal control. So we need to pay attention to NMS and treating at the early-stage of PD diseases.