高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究
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江苏省自然科学基金资助(BK2010419)


The change of plasma adiponectin level and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage
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    摘要:

    目的:高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究-方法:选择43例脑出血患者及30例对照组患者,用酶联免疫法检测其入院后第1-2-3-5-7天的血浆脂联素浓度及入院时白介素-6(IL-6)-肿瘤坏死因子-α(TNF-α)浓度,放射免疫法检测高敏C-反应蛋白(CRP)浓度,分析高血压脑出血后血浆脂联素与炎症因子之间的相关性-结果:患者脑出血后,血浆脂联素浓度在6 h内明显升高,在24 h达高峰,持续2 d后逐渐下降-实验组血浆脂联素浓度-CRP-IL-6及TNF-α均不同程度高于对照组-相关分析显示血浆脂联素浓度与炎症因子之间呈正相关-结论:高血压脑出血患者血浆脂联素呈动态变化过程,且可能与CRP-IL-6及TNF-α共同参与了脑出血后的炎症反应,是脑出血后脑组织损伤的重要机制之一-

    Abstract:

    Objective:To detect the change of plasma adiponectin and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage. Methods: Blood samples of 30 cases in control group and 43 patients with hypertensive cerebral hemorrhage were obtained 1,2,3,5,and 7 days after hospitalization. Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay were used to measured concentrations of plasma adiponectin,interleukin-6 (IL-6),C-reactive protein (CRP) and tumor necrosis factor-α(TNF-α). Results: After hypertensive cerebral hemorrhage,the level of plasma adiponectin increased immediately within 6 h,reached the peak at 24 h,and decreased gradually after 2 days. The adiponectin concentration was higher in patients with hypertensive cerebral hemorrhage than control group during 7 days. The levels of plasma IL-6,CRP,and TNF-α in patients with hypertensive cerebral hemorrhage were significantly higher than those in control group,and were associated with adiponectin level. Conclusion: The change of plasma adiponectin was a dynamic process. Together with IL-6,CRP,and TNF-α,plasma adiponectin may be involved in the inflammatory responses injury after cerebral hemorrhage.

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王 宏,王文宏,游 洋,苏 正.高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究[J].南京医科大学学报(自然科学版),2012,(3):378-381

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  • 收稿日期:2011-09-26
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