文章摘要
张晓鸣,顾绍庆.水飞蓟素对急性肺损伤小鼠肺组织IL-1β、IL-6、趋化因子fractalkine表达的影响[J].南京医科大学学报,2012,(8):1083~1086
水飞蓟素对急性肺损伤小鼠肺组织IL-1β、IL-6、趋化因子fractalkine表达的影响
The effects of silymarin on IL-1β,IL-6,fractalkine gene expression in lung tissue rats with acute lung injury
投稿时间:2012-03-30  
DOI:10.7655
中文关键词: 水飞蓟素  急性肺损伤  白介素-1β  白介素-6  fractalkine
英文关键词: silymarin  acute lung injury  IL-1β  IL-6  fractalkine
基金项目:
作者单位
张晓鸣 江苏大学附属医院儿科,江苏 镇江 212000 
顾绍庆 江苏大学附属人民医院儿科,江苏 镇江 212000 
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中文摘要:
      目的:探讨水飞蓟素(silymarin,SIL)对急性肺损伤小鼠肺组织中白细胞介素(interleukin,IL)-1β?IL-6?趋化因子fractalkine表达的影响与意义?方法:利用内毒素(lipopolysaccharide,LPS)气管内滴入制备小鼠急性肺损伤的模型;设立SIL治疗组(S组)?LPS组(L组)?生理盐水对照组(N组),S组在气管内滴入LPS前6?4?2 h以200 mg/kg水飞蓟素灌胃,分别在LPS处理后6?12?24 h取肺组织匀浆,用ELISA法分别测定各组IL-1β?IL-6?fractalkine蛋白水平?结果:在各时间点,S组肺组织中IL-1β?IL-6?fractalkine蛋白表达水平均显著低于L组?结论:SIL能有效抑制小鼠急性肺损伤时肺组织中IL-1β?IL-6?趋化因子fractalkine的表达?
英文摘要:
      Objective:To investigate the effects of silymarin (SIL) on the expressions of IL-1β,IL-6,and fractalkine in lung tissue of rat with acute lung injury. Methods:A rat model of acute lung injury (ALI) was induced by lipopolysaccharide (LPS). All rats were randomly divided into SIL group,LPS group and normal saline control group. SIL(200 mg/kg) was dropped into airway of rats in SIL group 6,4,and 2 h before treated with LPS. After LPS was given for 6,12 and 24 h,IL-1β,IL-6,chemotatic factor fractalkine protein levels in lung tissue homogenate were detected by ELISA. Results:At all time point,IL-1β,IL-6,fractalkine protein levels of SIL group were all significantly lower than those in LPS group(P < 0.05). Conclusion:SIL could significantly inhibit the expression of IL-1β,IL-6,fractalkine in lung tissue of rat with acute lung injury.
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