文章摘要
郝 涛,高 琳.2型糖尿病患者血浆纤维蛋白原与牙周病的关系[J].南京医科大学学报,2012,(8):1103~1105
2型糖尿病患者血浆纤维蛋白原与牙周病的关系
Correlation between plasma fibrinogen in type 2 diabetic patients and periodontal disease
投稿时间:2012-03-25  
DOI:10.7655
中文关键词: 2型糖尿病  牙周病  纤维蛋白原
英文关键词: type 2 diabetic mellitus  periodontal disease  plasma fibrinogen
基金项目:贵州省卫生厅科技基金项目(D-276);遵义医学院中青年科技基金项目(F-185)
作者单位
郝 涛 遵义医学院附属第一医院内分泌科,贵州 遵义 563003
都江堰市医疗中心,四川 都江堰 611830) 
高 琳 遵义医学院附属第一医院内分泌科,贵州 遵义 563003 
摘要点击次数: 953
全文下载次数: 669
中文摘要:
      目的:检测2型糖尿病伴重度牙周病患者血浆纤维蛋白原(plasma fibrinogen,Fbg)水平变化,探讨2型糖尿病患者Fbg与重度牙周病的关系?方法:选择2型糖尿病伴重度牙周病患者24例?糖尿病无牙周病患者20例?健康对照组16例,测定Fbg的同时,测定体质指数?血脂?糖化血红蛋白(HbA1c)等临床?生化指标?结果:2型糖尿病伴牙周病组血浆Fbg水平显著高于2型糖尿病无牙周病组及健康对照组,糖尿病无牙周病组显著高于对照组(P < 0.05);血浆Fbg与HbA1c?胰岛素抵抗指数(HOMA-IR)呈正相关?结论:牙周病可能导致2型糖尿病患者Fbg水平升高,这种炎性介质可能进一步加重糖?脂代谢异常,加重胰岛素抵抗?
英文摘要:
      Objective:To investigate plasma fibrinogen levels in type 2 diabetic patients with periodontal disease,and to explore the correlation between plasma fibrinogen and periodontal diseases in type 2 diabetic patients. Methods:The study included 24 type 2 diabetic patients complicated with severe periodontal diseases,20 type 2 diabetic patients without periodontal diseases and 16 normal controls. The body mass index(BMI) was calculated,and plasma fibrinogen and blood lipids,HbA1c were determined. Results:Compared with normal control and type 2 diabetic subjects without periodontal diseases,plasma fibrinogen levels in type 2 diabetic patients with severe periodontal diseases were significantly increased. Plasma fibrinogen level in type 2 diabetic patients without periodontal diseases was significantly elevated compared with normal controls(P < 0.05). The plasma fibrinogen levels were positively correlated with HOMA-IR?HbA1c. Conclusion:Periodontal diseases may result in higher circulating fibrinogen in type 2 diabetic patients,and aggravate glucose metabolic disorder and insulin resistance.
查看全文   查看/发表评论  下载PDF阅读器
关闭