2型糖尿病患者血浆纤维蛋白原与牙周病的关系
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贵州省卫生厅科技基金项目(D-276);遵义医学院中青年科技基金项目(F-185)


Correlation between plasma fibrinogen in type 2 diabetic patients and periodontal disease
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    目的:检测2型糖尿病伴重度牙周病患者血浆纤维蛋白原(plasma fibrinogen,Fbg)水平变化,探讨2型糖尿病患者Fbg与重度牙周病的关系-方法:选择2型糖尿病伴重度牙周病患者24例-糖尿病无牙周病患者20例-健康对照组16例,测定Fbg的同时,测定体质指数-血脂-糖化血红蛋白(HbA1c)等临床-生化指标-结果:2型糖尿病伴牙周病组血浆Fbg水平显著高于2型糖尿病无牙周病组及健康对照组,糖尿病无牙周病组显著高于对照组(P < 0.05);血浆Fbg与HbA1c-胰岛素抵抗指数(HOMA-IR)呈正相关-结论:牙周病可能导致2型糖尿病患者Fbg水平升高,这种炎性介质可能进一步加重糖-脂代谢异常,加重胰岛素抵抗-

    Abstract:

    Objective:To investigate plasma fibrinogen levels in type 2 diabetic patients with periodontal disease,and to explore the correlation between plasma fibrinogen and periodontal diseases in type 2 diabetic patients. Methods:The study included 24 type 2 diabetic patients complicated with severe periodontal diseases,20 type 2 diabetic patients without periodontal diseases and 16 normal controls. The body mass index(BMI) was calculated,and plasma fibrinogen and blood lipids,HbA1c were determined. Results:Compared with normal control and type 2 diabetic subjects without periodontal diseases,plasma fibrinogen levels in type 2 diabetic patients with severe periodontal diseases were significantly increased. Plasma fibrinogen level in type 2 diabetic patients without periodontal diseases was significantly elevated compared with normal controls(P < 0.05). The plasma fibrinogen levels were positively correlated with HOMA-IR-HbA1c. Conclusion:Periodontal diseases may result in higher circulating fibrinogen in type 2 diabetic patients,and aggravate glucose metabolic disorder and insulin resistance.

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郝 涛,高 琳.2型糖尿病患者血浆纤维蛋白原与牙周病的关系[J].南京医科大学学报(自然科学版),2012,(8):1103-1105

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  • 收稿日期:2012-03-25
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