文章摘要
邓国忠,唐国建,李小兰.中老年人群血清25羟-维生素D与血脂的关系[J].南京医科大学学报,2013,(11):1580~1583
中老年人群血清25羟-维生素D与血脂的关系
Relationship between serum 25-Hydroxy Vitamin D and lipid profiles among middle-aged and elderly individuals
投稿时间:2013-04-13  
DOI:10.7655/NYDXBNS20131123
中文关键词: 25羟-维生素D  血脂  中老年
英文关键词: 25-hydroxy Vitamin D,lipid profiles,middle-aged and elderly
基金项目:
作者单位
邓国忠 江苏大学附属金坛医院内分泌科,江苏 金坛 212300 
唐国建 江苏大学附属金坛医院中心实验室,江苏 金坛 212300 
李小兰 江苏大学附属金坛医院内分泌科,江苏 金坛 212300 
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中文摘要:
      目的:探讨中老年人群血清25羟-维生素D(25-OH VitD)与血脂各成分的关系。方法:研究纳入社区724例中老年人,采空腹静脉血并检测血清25-OH VitD及生化指标。根据血清25-OH VitD水平三分位分为低?中?高3组(T1?T2?T3)。采用单因素方差分析比较3组间血脂水平差别,多重线性回归分析校正混杂因素后25-OH VitD与血脂间的相关性。结果:甘油三酯(TG)水平在不同组间差异有显著性,各组间总胆固醇?低密度脂蛋白胆固醇和高密度脂蛋白胆固醇差异无统计学意义。25-OH VitD与TG间存在负性回归关系(回归系数 -0.013,P < 0.001),在整体人群及女性人群中校正了年龄?体质指数(BMI)?空腹血糖?糖化血红蛋白等代谢性因素后,回归系数仍有统计学意义。结论:随着血清25-OH VitD的降低,中老年人群的血清TG水平显著升高,25-OH VitD与TG水平存在显著负相关性,这种关系在女性人群中更密切,而25-OH VitD与胆固醇代谢关系不密切。
英文摘要:
      Objective:To investigate the relationship between serum 25-Hydroxy Vitamin D and lipid profiles among middle-aged and elderly population. Methods:Individuals of 724 were enrolled in this study. Fasting blood samples were collected and serum 25-Hydroxy Vitamin D and biochemical indices were determined. Subjects were divided into three groups (T1?T2?T3) according to tertiles of 25-Hydroxy Vitamin D levels. ANOVA was used to detect the difference among the three groups. Multiple linear regression was conducted to investigate relationships between 25- Hydroxy Vitamin D levels and lipid profiles. Results:There was significant difference among three groups for TG,but not for TC,HDL and LDL. 25-Hydroxy Vitamin D was associated with TG in total population(regression coefficient -0.013,P < 0.001). After adjustment for age,BMI,fasting blood glucose,HbA1c,glutamic transaminase,and γ-glutamyl transpeptidase,the association was still significant in all subjects and females. Conclusion:Middle-aged and elderly individuals with lower serum 25-Hydroxy Vitamin D had higher TG level. 25-Hydroxy Vitamin D is associated with TG negatively,and particularly in females. However there was no significant association between 25-Hydroxy Vitamin D and TC,HDL or LDL.
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