文章摘要
丁重阳,李天女,杨文平,孙 晋,徐绪党.18F-FDG PET/CT在弥漫大B细胞淋巴瘤临床分期及评价化疗反应中的价值[J].南京医科大学学报,2014,(1):094~098
18F-FDG PET/CT在弥漫大B细胞淋巴瘤临床分期及评价化疗反应中的价值
The value of 18F-FDG PET/CT for clinical staging and assessing therapeutic response to chemotherapy in patients with diffuse large B-cell lymphoma
投稿时间:2013-06-17  
DOI:10.7655/NYDXBNS20140123
中文关键词: 淋巴瘤  大B细胞  弥漫性  药物疗法  正电子发射型计算机断层扫描  18F-FDG  临床分期
英文关键词: lymphoma  large B-cell  diffuse  drug therapy  positron emission tomography  fluorine-18 fluoro-deoxy-glucose  clinical staging
基金项目:国家自然科学基金青年基金(81202032)
作者单位
丁重阳 南京医科大学第一附属医院核医学科,江苏 南京 210029 
李天女 南京医科大学第一附属医院核医学科,江苏 南京 210029 
杨文平 南京医科大学第一附属医院核医学科,江苏 南京 210029 
孙 晋 南京医科大学第一附属医院核医学科,江苏 南京 210029 
徐绪党 南京医科大学第一附属医院核医学科,江苏 南京 210029 
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中文摘要:
      目的:探讨18F-FDG PET/CT对弥漫大B细胞淋巴瘤(diffuse B-cell large lymphoma,DLBCL)临床分期及评价化疗中期治疗反应的价值?方法:29例初诊的DLBCL化疗前和化疗中期均行18F-FDG PET/CT检查,根据肿瘤对化疗的反应将病例分为无反应组?部分反应组及完全反应组,采用χ2检验和Fisher确切概率法比较3组患者的完全缓解率?结果:18F-FDG PET/CT改变了10.3%(3/29)患者的临床分期?无反应组?部分反应组及完全反应组的临床完全缓解率分别为16.7%(1/6)?69.2% (9/13) 和80.0% (8/10),3组间差异有统计学意义(χ2 = 7.033,P = 0.030)?完全反应组?部分反应组的完全缓解率明显高于无反应组(χ2 = 4.310,P = 0.038;χ2 = 5.730,P = 0.017)?结论:18F-FDG PET/CT显像有助于临床分期;化疗中期18F-FDG PET/CT显像有助于预测化疗疗效?
英文摘要:
      Objective:To explore the value of 18F-FDG PET/CT on clinical staging and assessment of chemotherapy response in patients with diffuse large B-cell lymphoma(DLBCL). Methods:18F-FDG PET/CT was performed before and after 3 or 4 cycles of chemotherapy in 29 patients with DLBCL. The patients were divided into three the groups:no response group,the partial response group and the complete response group. We compared the complete remission rate(CR) between the three groups. χ2 test and Fisher exact test were performed with SPSS 17.0. Results:The stage of disease was changed in three patients(10.3%,3/29)on the basis of pre-treatment 18F-FDG PET/CT. CR rates of the no response group,the partial response group and the complete response group were 16.7%,69.2% and 80.0%,respectively(χ2 = 7.033,P = 0.030). CR rates of the complete response group and the partial response group were significantly higher than those of the no response group(χ2 = 4.310,P = 0.038;χ2 = 5.730,P = 0.017). Conclusion:18F-FDG PET/CT may be useful for clinical staging and assessment of chemotherapy response of middle stage in DLBCL.
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