文章摘要
朱晓慧,郭雯,付真真,高贝贝,陈晓丽,符金香,周红文.女性2型糖尿病患者绝经前后血清CETP活性的差异及其影响因素[J].南京医科大学学报,2014,(4):482~485
女性2型糖尿病患者绝经前后血清CETP活性的差异及其影响因素
Comparison of serum CETP activity between premenopausal and postmenopausal women with type 2 diabetes and its influencing factors
投稿时间:2013-11-13  
DOI:10.7655/NYDXBNS20140416
中文关键词: 胆固醇酯转运蛋白  高密度脂蛋白胆固醇  绝经
英文关键词: cholesteryl ester transfer protein  high-density lipoprotein cholesterol  menopause
基金项目:国家自然科学基金(81170747);江苏省六大人才高峰(2008-18D)
作者单位
朱晓慧 南京医科大学第一附属医院内分泌科,江苏南京210029 
郭雯 南京医科大学第一附属医院内分泌科,江苏南京210029 
付真真 南京医科大学第一附属医院内分泌科,江苏南京210029 
高贝贝 南京医科大学第一附属医院内分泌科,江苏南京210029 
陈晓丽 南京医科大学第一附属医院内分泌科,江苏南京210029 
符金香 南京医科大学第一附属医院内分泌科,江苏南京210029 
周红文 南京医科大学第一附属医院内分泌科,江苏南京210029 
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中文摘要:
      目的:探讨女性2型糖尿病患者绝经前后血清胆固醇酯转运蛋白(CETP)活性的差异及其与代谢因素的相关关系?方法:收集2011年9月~2012年6月在南京医科大学第一附属医院内分泌科住院的113名女性2型糖尿病患者空腹血样本,整理这些患者的临床病例资料?用荧光酶法检测血样本CETP活性,并检测其他重要生化指标?结果:女性2型糖尿病人群中血清CETP活性与年龄?体质指数(BMI)?甘油三酯(TG)?空腹血糖(FBG)?糖化血红蛋白(HbA1c)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关,而与收缩压(SP)?舒张压(BP)?总胆固醇(TC)?低密度脂蛋白胆固醇(LDL-C)?脂蛋白(a)[Lp(a)]?空腹胰岛素?HOMA胰岛素抵抗指数(HOMA-IR)?肌酐(Cr)?尿素(Urea)?尿酸(UA)?丙氨酸氨基转移酶(ALT)?天门冬氨酸氨基转移酶(AST)?碱性磷酸酶(ALP)?直接胆红素(TBIL)没有明显相关关系?绝经前女性2型糖尿病患者血清CETP活性[(3.55 ± 0.24)?滋g/ml]低于绝经后女性[(3.99 ± 0.28)?滋g/ml],且差别具有统计学意义(P < 0.01)?结论:女性2型糖尿病患者绝经后的CETP活性高于绝经前,且CETP活性与年龄?HDL-C密切相关?
英文摘要:
      Objective:To investigate the difference of serum CETP activity between premenopausal and postmenopausal women with type 2 diabetes and its relevant metabolic factors. Methods:Fasting blood samples were collected from 113 subjects hospitalized in Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University from September 2011 to June 2012. All these subjects were female patients with type 2 diabetes before and after menopause. CETP activity and some biochemical markers of the subjects were measured. Results:Serum CETP activity of patients with type 2 diabetes was positively correlated with age,BMI,TG,FBG,HbA1c,and was negatively correlated with HDL-C. There was no obvious correlation between serum CETP activity and SP,BP,TC,LDL-C,Lp (a),fasting insulin levels,HOMA-IR,Cr,Urea,UA,ALT,AST,ALP and TBIL. Serum CETP activity of premenopausal women [(3.55 ± 0.24)?滋g/ml] was lower than that of postmenopausal women [(3.99 ± 0.28)?滋g/ml],and the difference was statistically significant(P < 0.01). Conclusion:CETP activity of premenopausal women is lower than that of postmenopausal women,and CETP activity is closely related with age and HDL-C levels.
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