Objective:To investigate the association between serum uric acid(SUA)and nonalcoholic fatty liver disease(NAFLD) in type 2 diabetic patients(T2DM). Methods:A total of 533 T2DM subjects were recruited to undergo anthropometric measurements and fasting blood sampling for biochemical assay such as blood glucose,lipid,uric acid and insulin. All subjects were divided into four groups according to the quartiles of SUA,and we compared the differences of metabolic indexes among them and analyzed the association between SUA level and NAFLD. Results:BMI,SBP,TG,fasting insulin and insulin resistance index(HOMA-IR)were significantly elevated with the increase of SUA concentration(P for trend < 0.05). Similarly,ALT and AST was increased with the elevation of SUA. The prevalence rates of NAFLD in participants with increasing SUA quartiles were 41.2%,54.9%,59.3% and 71.8%,respectively(P for trend < 0.001). Logistic regression analysis showed that the risk of NAFLD was increased by 239% in participants of the fourth SUA quartile as compared with participants in the first quartile. Conclusion:SUA was significantly and independently associated with NAFLD in T2DM patients.