文章摘要
解翠薇,薛文杰,杜江波,靳光付.端粒长度与肿瘤发生发展的研究进展[J].南京医科大学学报,2016,(6):641~647
端粒长度与肿瘤发生发展的研究进展
Research progress of telomere length and cancer
投稿时间:2016-04-26  
DOI:10.7655/NYDXBNS20160601
中文关键词: 端粒  端粒酶  肿瘤  遗传变异
英文关键词: telomere  telomerase  cancer  genetic variant
基金项目:国家自然科学基金(81422042);江苏省高等学校大学生实践创新训练计划(201310312003Z);江苏高校品牌专业建设工程资助项目(PPZY2015A067);江苏高校优势学科建设工程项目
作者单位
解翠薇 南京医科大学公共卫生学院流行病学系,江苏 南京 211166 
薛文杰 南京医科大学公共卫生学院流行病学系,江苏 南京 211167 
杜江波 南京医科大学公共卫生学院流行病学系,江苏 南京 211168 
靳光付 南京医科大学公共卫生学院流行病学系,江苏 南京 211169 
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中文摘要:
      端粒是染色体末端维持染色体完整和基因组稳定的重要串联重复序列结构?端粒长度可通过多种方法进行定量或相对定量检测,反映机体在细胞水平的衰老程度和健康状态?端粒酶能够以自身模板序列催化合成端粒并使之延长?端粒在肿瘤发生发展过程中发挥重要作用,端粒长度可作为一类分子标志物指示肿瘤发生发展风险?近年来,许多研究对端粒长度及其相关因素与多种肿瘤发生发展的关系进行了探讨,发现其在不同肿瘤中可能发挥不同作用?本文对国内外相关领域的研究进展进行了梳理和汇总?
英文摘要:
      Telomeres consisting of tandem repetitive sequence,which cap the ends of chromosomes are crucial in maintaining chromosomal integreity and genome stability. Many methods can be used to quantitatively or relative quantitatively measure telomere length. Telomere length can reflect the degree of celluaraging and health status of the organism. The telomerase reverse transcriptase can lengthen telomere by synthesising telomere with its own template sequence. Telomere length and telomerase have been implicated with the development of cancer. Genetic and environmental factors can influence telomere length. Telomere length has the potential to be a biomarker to indicate the risk of cancer development and progression. To date,a series of studies have been conducted to evaluate the relationship between telomere length and cancer risk,and found a different role in different tumors. Therefore,we reviewed and summarized the progression in this field around the world.
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