文章摘要
田 薇,章建国,刘益飞,王东林,黄 华.CDK4和Geminin在胶质瘤中的表达及其与预后的关系[J].南京医科大学学报,2017,(6):709~713
CDK4和Geminin在胶质瘤中的表达及其与预后的关系
Expression and prognostic significance of CDK4 and Geminin in human glioma
投稿时间:2016-08-29  
DOI:10.7655/NYDXBNS20170611
中文关键词: 胶质瘤  周期蛋白依赖性激酶4  Geminin
英文关键词: glioma  cyclin-dependent kinase 4  Geminin
基金项目:国家自然科学基金面上项目(81572491)
作者单位
田 薇 南通大学附属医院病理科江苏 南通 226000 
章建国 南通大学附属医院病理科江苏 南通 226000 
刘益飞 南通大学附属医院病理科江苏 南通 226000 
王东林 南通大学医学院病理教研室江苏 南通 226000 
黄 华 南通大学附属医院病理科江苏 南通 226000 
摘要点击次数: 743
全文下载次数: 647
中文摘要:
      目的:探讨细胞周期依赖性激酶4(cyclin-dependent kinase 4,CDK4)和Geminin在胶质瘤中的表达及其临床病理意义。方法:采用免疫组织化学方法,检测70例胶质瘤中CDK4和Geminin的表达,分析CDK4和Geminin的表达和其相关性,以及二者与胶质瘤临床病理因素及生存时间的关系。 结果:CDK4、Geminin在胶质瘤中的总阳性率分别为70.0%(49/70)、75.7%(53/70);Ⅱ、Ⅲ、Ⅳ级胶质瘤中CDK4阳性率分别为52.8%(19/36)、84.6%(22/26)、100.0%(8/8),Geminin阳性率分别为58.3%(21/36)、92.3%(24/26)、100.0%(8/8),CDK4和Geminin在不同级别胶质瘤中的表达有显著差异(P<0.05)。且二者表达呈正相关;CDK4、Geminin阳性表达与肿瘤大小及细胞核分裂像多少有关(P<0.05),与患者年龄、性别以及肿瘤组织有无坏死无关(P>0.05);Kaplan-Meier单因素统计分析结果显示 CDK4、Geminin阳性表达组的患者术后生存时间明显短于CDK4、Geminin阴性表达组(P<0.001)。结论:CDK4和Geminin表达与胶质瘤的分级、预后有关,联合检测CDK4和Geminin有助于判断胶质瘤恶性程度及评估预后。
英文摘要:
      Objective: To investigate the difference of expression and prognostic significance of cyclin-dependent kinase 4 (CDK4) and Geminin in gliomas. Methods: Immunohistochemical was used to detect the expressions of CDK4 and Geminin in 70 human gliomas. Their relationships with clinicopathologic factors and survival time of patients were also analyzed. Results: The positive rates of CDK4 and Geminin in gliomas were 70.0%(49/70) and 75.7%(53/70),respectively. The positive rates of CDK4 in gradeⅡ, grade Ⅲ, grade Ⅳ of gliomas were 52.8%(21/36), 84.6%(22/26) and 100.0%(8/8), and the positive rates of Geminin in grad Ⅱ, Ⅲ and Ⅳ were 58.3%(21/36),92.3%(24/26) and 100.0%(8/8),respectively. A statistical significance of their expressions was observed among different grades (P<0.05). The expressions of them were positively correlated. The positive expressions of Geminin and CDK4 were related to the tumor size and the number of nuclear division(P<0.05),and were not related to age,sex and necrosis of tumor tissue(P>0.05). Kaplan-Meier univariate statistical analysis showed that the survival time of patients with positive CDK4 and Geminin expression group was significantly shorter than that of the negative CDK4 and Geminin expression group(P<0.001). Conclusion: The expressions of CDK4 and Geminin are related to the grading of gliomas and prognosis. Combined detection of CDK4 and Geminin is helpful to judge the malignant degree and prognosis of gliomas.
查看全文   查看/发表评论  下载PDF阅读器