Objective: To identify risk factors associated with treatment resistant hypertension（TRH） and easily detectable through routine blood tests in chronic kidney disease（CKD） patients, who received hemodialysis. Methods: One hundred and seventy-four CKD patients with hypertension receiving hemodialysis between December 2009 and June 2015 were enrolled in this study. Of these patients, 69 patients had TRH; the other 105 patients had not. Univariate and multivariate logistic regression analysis was used to assess risk factors associated with TRH. Results: In our study population, the gender distribution, serum level of creatinine and hemodialysis duration were comparable between two groups. The mean age，serum leves of uric acid(UA), white blood cell numbers, aspertate aminotransferase(AST)，gamma-glutamyl transferase(GGT) and adenosine deaminase(ADA) were lower in the case group than those in the control group. The serum level of calcium and albumin(ALB) was higher in the case group than that in the control group. Age younger than 40（OR：3.350，P=0.010），GGT less than 20 U/L（OR：2.554，P=0.024）, 10≤AST<15 U/L（OR：2.499，P=0.011）, and ADA less than 12 U/L（OR：2.259，P=0.044） were positively correlated with TRH. Meanwhile, serum level of ALB less than 41 g/L（OR：0.298，P=0.002） was negatively correlated with TRH. Stepwise multi-variate logistic regression showed that ALB was positively（OR：1.130，P=0.002） and ADA was negatively（OR：0.900，P=0.027） correlated with TRH. Conclusion: The younger age(＜40 years) and lower serum level of GGT(＜20 U/L), AST(10 U/L≤AST＜15 U/L) and ADA(＜12 U/L) are risk factors, and serum levels of ADA decreasing and ALB increasing are independent risk factors for TRH in hemodialysis patients.