文章摘要
孟 荔,史爱武.微小RNA在心血管疾病中的研究进展[J].南京医科大学学报,2018,(4):562~568
微小RNA在心血管疾病中的研究进展
Research advances of miRNAs in cardiovascular diseases
投稿时间:2017-07-05  
DOI:10.7655/NYDXBNS20180431
中文关键词: 微小RNA  心血管疾病  生物标志物  靶向治疗
英文关键词: microRNAs  cardiovascular diseases  biomarkers  targeted therapy
基金项目:南京市科技局/南京市卫生局重点项目(201405042/ZKX14042);南京医科大学科技发展基金重点项目(2015NJMUZD058)
作者单位
孟 荔 南京医科大学附属妇产医院MICU江苏 南京 210004 
史爱武 南京医科大学附属妇产医院MICU江苏 南京 210004 
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中文摘要:
      微小RNA(microRNA,miRNA)是一类长18~24个核苷酸的高度保守的小分子非编码RNA,可调节转录后基因的表达。自miRNA发现以来,大量研究显示miRNA参与多种心血管疾病的调节,包括心肌肥厚、心律失常、高血压、动脉粥样硬化、急性冠脉综合征及心肌梗死、心力衰竭、肺动脉高压等;此外,在心血管领域,循环miRNA被作为新的生物标志物被深入研究;miRNA的多种调控功能预示miRNA在心血管疾病治疗方面具有广泛的应用前景。然而,在miRNA作为心血管疾病诊断和预后分析的生物标志物及靶向治疗策略应用于临床之前,还有许多问题尚未解决,仍需进行大量深入和系统的研究。
英文摘要:
      MicroRNAs(miRNAs)are highly conserved,small and non?coding RNA molecules approximately 18?24 nucleotides in length which act as post?transcriptional regulators of gene expression. Since their discovery,miRNAs have been shown to regulate the complex biological processes linked to multiple cardiovascular diseases,including myocardial hypertrophy,arrhythmias,hypertension,atherosclerosis,acute coronary syndrome(ACS),acute myocardial infarction(AMI),heart failure(HF),pulmonaryarterial hypertension(PAH)and etc. Furthermore,circulating miRNAs have been extensively investigated as novel biomarkers. Besides that,the multiple regulatory functions of miRNAs indicate that miRNAs have prospective applications in the treatment of cardiovascular disease. However,there are still significant obstacles that need to be overcome before miRNAs are used as both diagnostic and prognostic biomarkers and targeted therapy strategies for cardiovascular diseases,and there is still a need for extensive and systematic research.
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