文章摘要
何淑娟,许家艳,贾 嫚,欧英炜,周 军,姚 欣.血清斯钙素⁃1在稳定期慢性阻塞性肺病中的表达及意义[J].南京医科大学学报,2018,(10):1404~1408
血清斯钙素⁃1在稳定期慢性阻塞性肺病中的表达及意义
Expression and role of serum stanniocalcin⁃1 in chronic obstructive pulmonary disease
投稿时间:2018-08-20  
DOI:10.7655/NYDXBNS20181015
中文关键词: 慢性阻塞性肺病  斯钙素⁃1
英文关键词: chronic obstructive pulmonary disease(COPD)  stanniocalcin⁃1(STC1)
基金项目:
作者单位
何淑娟 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
许家艳 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
贾 嫚 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
欧英炜 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
周 军 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
姚 欣 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
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中文摘要:
      目的:探讨斯钙素?1(stanniocalcin?1,STC1)在稳定期慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)患者血清中的表达及意义。方法:收集55例稳定期COPD患者,根据肺功能和问卷评分进行相应分组,且以24例健康者作为对照。采用酶联免疫吸附法(ELISA)测定各研究对象的血清斯钙素?1表达情况,进行相关分析。结果:①与健康对照组相比,稳定期COPD患者血清斯钙素?1表达水平明显降低(P < 0.05)。②血清斯钙素?1在初筛COPD上具有一定价值(P=0.025,AUC=0.659),最佳阈值为1 350 pg/mL(敏感度81.82%;特异度50.00%)。③血清斯钙素?1与稳定期COPD患者病情严重程度[包括GOLD分级、慢阻肺评估测试(COPD assessment test,CAT)评分、ABCD分组、肺功能]无明显相关性。结论:血清斯钙素?1在COPD中显著降低,可能对于COPD的诊治具有一定临床意义。
英文摘要:
      Objective:To investigate the serum level of stanniocalcin?1(STC1) in patients with stable chronic obstructive pulmonary diseases(COPD) and to explore the relationship between STC1 and severity of the disease. Method:A total of 55 patients with definite stable COPD and 24 healthy controls were enrolled in this study. Serum STC1 was measured by enzyme?linked immunosorbent assay(ELISA),and the correlation between STC1 and COPD was analyzed. Results:①Serum STC1 levels were significantly lower in patients with COPD than healthy controls(P < 0.05). ②The receiver?operating characteristic(ROC) curve of serum SCT1 was used for threshold identification(AUC=0.659,P=0.025),the optimal cut?off point of serum STC1 was 1 350 pg/mL(sensitivity 81.82%,specificity 50.00%,respectively). ③Poor association of serum STC1 levels with stable COPD was found,including the GOLD classification,COPD assessment test(CAT) scores and lung functions. Conclusion:Serum STC1 levels were significantly decreased in COPD patients while it is poorly correlated with disease severity. STC1 might have clinical application in stable COPD.
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