文章摘要
张余春,王 昆,马向华.甲状腺结节术前基因诊断的研究进展[J].南京医科大学学报,2018,(10):1472~1476
甲状腺结节术前基因诊断的研究进展
Research progress of preoperative genetic diagnosis in thyroid nodule
投稿时间:2018-07-27  
DOI:10.7655/NYDXBNS20181032
中文关键词: 甲状腺结节  基因诊断  甲状腺恶性肿瘤  肿瘤标志物
英文关键词: thyroid nodules  genetic diagnosis  thyroid cancers  tumor marker
基金项目:国家自然科学基金(81870542);江苏省科技计划项目(BE2017736)
作者单位
张余春 南京医科大学第一附属医院内分泌科江苏 南京 210029
南京医科大学附属江宁医院内分泌科江苏 南京 211100 
王 昆 南京医科大学附属江宁医院内分泌科江苏 南京 211100 
马向华 南京医科大学第一附属医院内分泌科江苏 南京 210029 
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中文摘要:
      甲状腺结节的检出率和发病率逐年上升,超声引导下的细针穿刺细胞学检查(fine needle aspiration,FNA)是术前评估甲状腺结节性质的金标准。然而20%~30%的甲状腺结节通过FNA仍无法明确诊断,此类结节的患者往往接受诊断性手术治疗,术后病理结果证实为良性结节,大部分结节都接受了不必要的手术,而通过基因检测实现术前精确诊断可以避免过度治疗。本文综述甲状腺结节的基因诊断研究进展以及对甲状腺结节的风险评估、疗效预测和预后判断的临床价值。
英文摘要:
      The detection rate and incidence of thyroid nodules have increased year by year. Ultrasound?guided fine needle aspiration cytology(FNA)is the gold standard for preoperative evaluation of the nature of thyroid nodules. However,approximately 20% to 30% of thyroid nodules by FNA are not clearly benign or malignant. Patients with such nodules are often received diagnostic surgery. Most nodules are confirmed benign lesions by postoperative pathological findings. Thus,those nodules have accepted unnecessary surgery. Preoperative accurate diagnoses like genetic tests are used to identify benign or malignant nodules to avoid overtreatment. This article reviews the genetic diagnosis advances and clinical value of risk assessment,efficacy prediction,and prognosis for thyroid nodules.
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