Objective：To analyze risk factors of hyperuricemia（HUA）in patients with newly diagnosed type 2 diabetes mellitus（T2DM）. Methods：A total of 735 patients with newly-diagnosed T2DM from the First Affiliated Hospital of NMU were enrolled in this case-control study from March 2010 to March 2017. The general clinical data and biochemical indicators of the patients were collected，and the related factors affecting the level of serum uric acid were analyzed. Results：The patients were divided into two groups according to with or without HUA，110 patients with HUA while 625 patients without HUA. The age，lipoprotein A，and estimated glomerular filtration rate（eGFR）in the T2DM with HUA group were all significantly lower than those patients without HUA（P＜0.05）. Besides，the body mass index（BMI），alanine aminotransferase（ALT），aspartic transaminase（AST），gamma-glutamyl transpeptidase（γGGT），triglyceride（TG），creatinine（Cr）and retinol binding protein（RBP）of the T2DM with HUA group were significantly higher than those of T2DM without HUA group（P＜0.05）. Logistic regression analysis revealed that male，low age，high BMI，high TG and low eGFR in the newly diagnosed T2DM patients were independent risk factors complicated with HUA. Conclusion：In the newly diagnosed T2DM patients，males who were relatively young，overweight，with hypertriglyceridemia and low eGFR，should be paid more attention on the comprehensive management of hyperuricemia.