文章摘要
张 琰,金 华,王适之.长链非编码RNA在宫颈癌中的研究进展[J].南京医科大学学报,2019,(2):306~312
长链非编码RNA在宫颈癌中的研究进展
Research progress of long non⁃coding RNA in cervical cancer
投稿时间:2018-07-19  
DOI:10.7655/NYDXBNS20190232
中文关键词: 宫颈癌  长链非编码RNA  作用机制
英文关键词: cervical cancer  long non⁃coding RNA  mechanism
基金项目:江苏省自然科学基金(BK20171367);中央高校基本科研业务费专项资金资助(2242018K40020)
作者单位
张 琰 东南大学公共卫生学院江苏 南京 210009 
金 华 南通市肿瘤医院检验科江苏 南通 226361 
王适之 东南大学公共卫生学院江苏 南京 210009 
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中文摘要:
      宫颈癌的发生和发展是一个复杂的病理过程,除了人乳头瘤病毒(HPV)感染外,癌基因的激活和抑制基因的失活也在癌症过程中发挥了重要作用。长链非编码RNA(LncRNA)是长度大于200个核苷酸、不能编码蛋白质的长RNA转录物。一些lncRNA在肿瘤中表达异常,可作为癌基因或抑癌基因参与细胞通路调控,并与肿瘤发生、发展及转移密切相关。越来越多的证据表明,一些lncRNA在宫颈癌细胞中表达异常,可通过多种途经调控宫颈癌细胞的增殖、迁移与凋亡,并且与肿瘤的大小、血管生成、晚期FIGO分期、淋巴结转移和不良预后密切相关,是宫颈癌诊断与预后的重要指标和潜在治疗靶点。
英文摘要:
      The occurrence and development of cervical cancer is a complex pathological process. In addition to HPV infection,oncogene activation and inactivation of suppressor genes play an important role in the cancer process. LncRNAs are long RNA transcripts,which are longer than 200 nucleotides and are unable to encode proteins. Some lncRNAs are abnormally expressed in tumors and can be involved in the cellular pathways regulation as oncogenes or tumor suppressor genes,and are closely related to its development and metastasis. There are growing evidences that some lncRNAs are abnormally expressed in cervical cancer cells,and there are various ways to regulate their proliferation,migration and apoptosis. LncRNAs are closely related to tumor size,angiogenesis,FIGO late stage,lymph node metastasis and poor prognosis of cervical cancer. They are important indicators for diagnosis and prognosis,and also are potential therapeutic targets.
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