文章摘要
张 喆,贾立周,唐 奇,徐新宇,徐 玮,朱淼琳,冯振卿.TROP2和VEGFR2在三阴性乳腺癌中的表达及与临床病理因素的相关性研究[J].南京医科大学学报,2019,(10):1453~1458
TROP2和VEGFR2在三阴性乳腺癌中的表达及与临床病理因素的相关性研究
Expressions of TROP2 and VEGFR2 and their relationship with clinico⁃pathological factors in triple negative breast cancer
投稿时间:2019-07-16  
DOI:10.7655/NYDXBNS20191009
中文关键词: 三阴性乳腺癌  TROP2  VEGFR2  预后
英文关键词: TNBC  TROP2  VEGFR2  prognosis
基金项目:国家自然科学基金(81773100)
作者单位
张 喆 南京医科大学病理学系国家卫健委抗体技术重点实验室江苏 南京 211166南京医科大学附属肿瘤医院病理科江苏 南京 210009 
贾立周 南京医科大学病理学系江苏 南京 211166 
唐 奇 南京医科大学国家卫健委抗体技术重点实验室江苏 南京 211166 
徐新宇 南京医科大学附属肿瘤医院病理科江苏 南京 210009 
徐 玮 南京医科大学附属肿瘤医院病理科江苏 南京 210009 
朱淼琳 南京医科大学附属肿瘤医院病理科江苏 南京 210009 
冯振卿 南京医科大学病理学系国家卫健委抗体技术重点实验室江苏 南京 211166 
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中文摘要:
      目的:观察人滋养层细胞表面抗原2(TROP2)和血管内皮生长因子受体2(VEGFR2)在三阴性乳腺癌中的表达及与临床病理因素和预后的相关性。方法:应用免疫组化(两步法)检测151例三阴性乳腺癌、137例非三阴性乳腺癌、48例乳腺良性肿瘤以及48例正常乳腺组织中TROP2和 VEGFR2的蛋白表达情况,结合临床病理资料综合分析其临床意义和预后价值。结果:TROP2和VEGFR2分别在乳腺癌细胞的细胞膜和细胞质表达。TROP2和VEGFR2蛋白在三阴性乳腺癌中高表达,阳性率高于非三阴性乳腺癌、乳腺良性肿瘤和正常乳腺组织,并且TROP2和VEGFR2共同在三阴性乳腺癌高表达,高于非三阴性乳腺癌,差异有统计学意义。三阴性乳腺癌组织中TROP2阳性表达、VEGFR2阳性表达,以及TROP2和VEGFR 2在三阴性乳腺癌中的共同高表达与患者的组织学分级、临床分期、远处转移有相关性。TROP2和VEGFR2蛋白共同高表达是三阴性乳腺癌的独立预后指标。结论:TROP2和VEGFR2可以作为三阴性乳腺癌新的分子靶点,有望用于三阴性乳腺癌的预后评价和免疫靶向治疗。
英文摘要:
      Objective:To observe the expressions of human trophoblast cell surface antigen 2(TROP2)and vascular endothelial growth factor receptor 2(VEGFR2)in triple negative breast cancer(TNBC),and explore their correlation with clinicopathological factors and prognosis. Methods:The expressions of TROP2 and VEGFR2 in 151 cases of TNBC,137 cases of non?TNBC,48 cases of benign breast tumor and 48 cases of normal breast tissues were detected by immunohistochemical method(two?step method). Results:TROP2 and VEGFR2 were expressed in the cell membrane and cytoplasm of breast cancer cells,respectively. The TROP2 and VEGFR2 protein was highly expressed in TNBC,and their positive rates were higher than those in non?TNBC,benign breast tumor and normal breast tissues. The co?expression of TROP2 and VEGFR2 in TNBC was higher than that in non? TNBC,and the difference was statistically significant. The positive expressions of TROP2 and VEGFR2 in TNBC tissues and the high co?expression of TROP2 and VEGFR2 in TNBC were associated with the histological grade,clinical stage and metastasis of patients. The high co?expression of TROP2 and VEGFR2 proteins is an independent prognostic index of TNBC. Conclusion:TROP2 and VEGFR2 can be used as a new molecular target for TNBC,which can be expected to facilitate the prognosis evaluation and immune?targeting treatment of TNBC.
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