文章摘要
邱天竹,李晓林.老年胆道系统恶性肿瘤根治术后生存及预后分析[J].南京医科大学学报,2019,(12):1751~1754
老年胆道系统恶性肿瘤根治术后生存及预后分析
Analysis of overall survival and prognostic factors in elderly biliary tract cancer patients treated with radical resection
投稿时间:2019-06-11  
DOI:10.7655/NYDXBNS20191209
中文关键词: 胆道系统恶性肿瘤  根治术  老年人  生存分析  预后影响因素
英文关键词: biliary tract cancer  radical resection  elderly patients  survival analyse  prognostic factors
基金项目:国家自然科学基金面上项目(81672411)
作者单位
邱天竹 南京医科大学第一附属医院肿瘤科江苏 南京 210029 
李晓林 南京医科大学第一附属医院老年消化科江苏 南京 210029 
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中文摘要:
      目的:分析老年胆道系统恶性肿瘤根治术患者的远期生存状态并探讨影响其预后的临床病理因素。方法:回顾性分析2011年1月—2015年12月在南京医科大学第一附属医院行胆道系统恶性肿瘤根治术的143例>65岁患者的临床病理资料及随访资料,采用Kaplan?Meier法单因素分析和COX 单因素及多因素分析统计其总生存期(overall survival,OS)并分析其影响因素。结果:所有患者的中位OS为20.0个月。通过Kaplan?Meier法及COX回归风险模型单因素分析,结果显示浸润深度、淋巴结转移情况、组织分级、脉管侵犯、切缘阳性与否、术前乳腺脱氢酶(lactate dehydrogenase,LDH)水平与总生存期相关;COX 多因素分析显示浸润深度、组织分级、术前LDH水平是老年胆道系统恶性肿瘤根治术患者的危险因素。结论:老年胆道系统恶性肿瘤根治术患者总生存期与浸润深度、组织分级、术前LDH水平相关。
英文摘要:
      Objective:This studt aims to explore the prognostic factors in elderly operable biliary tract cancer patients treated with radical resection. Methods:The clinicopathologic and follow?up data of 143 elderly patients(>65 years old)with biliary tract cancer treated with radical resection from January 2011 to December 2015 were analyzed retrospectively. Results:Univariate analysis showed that depth of tumor invasion,lymph node involvement,histological differentiation,lymphovascular invasion,resection margin,lactate dehydrogenase(LDH)level were correlated to recurrence and metastasis of biliary tract cancer after radical resection. Multivariate analysis showed that depth of tumor invasion,histological differentiation and LDH level were independent factors affecting the prognosis of elderly biliary tract cancer patients. Conclusion:The overall survival of elderly operable biliary tract cancer patients was correlated with tumor invasion, histological differentiation and LDH level before radical resection.
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