文章摘要
杨丽娜,张 鵾.胃肠转流术对糖尿病大鼠降糖作用及GLP⁃1和IGF⁃1水平的影响[J].南京医科大学学报,2020,(1):45~49
胃肠转流术对糖尿病大鼠降糖作用及GLP⁃1和IGF⁃1水平的影响
Hypoglycemic effect of gastrointestinal bypass and the changes of GLP⁃1 and IGF⁃1 levels in diabetic rats
投稿时间:2018-11-28  
DOI:10.7655/NYDXBNS20200109
中文关键词: 胃肠转流术  糖尿病  大鼠  胰高血糖素样肽⁃1  胰岛素样生长因子⁃1
英文关键词: gastrointestinal bypass  diabetes mellitus  rat  glucagon like peptide⁃1  insulin⁃like growth factor⁃1
基金项目:
作者单位
杨丽娜 济南市第六人民医院内分泌科山东 济南 250200 
张 鵾 济南市第六人民医院胃肠外科山东 济南 250200 
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中文摘要:
      目的:探究胃肠转流术对糖尿病大鼠的降糖作用及胰高血糖素样肽?1(glucagon like peptide ?1,GLP?1)和大鼠胰岛素样生长因子?1(insulin?like growth factor ?1,IGF?1)水平的影响。方法:SD大鼠60只,随机分为对照组、假手术组、十二指肠转流组和空肠转流组,假手术组、十二指肠转流组和空肠转流组大鼠腹腔注射1%链脲佐菌素复制糖尿病模型,再分别进行相应手术操作,于术前以及术后第1、3和8周检测各组大鼠血糖、胰岛素、GLP?1和IGF?1水平。结果:对照组和假手术组大鼠的存活率均为100.00%,十二指肠转流组和空肠转流组存活率分别为93.33%、86.67%。术前假手术组、十二指肠转流组和空肠转流组血糖、GLP?1、IGF?1水平均显著高于对照组,胰岛素水平显著低于对照组(P < 0.05);术后第3周和第8周,十二指肠转流组和空肠转流组的体重和血糖低于同时间点假手术组,胰岛素、GLP?1和IGF?1水平高于同时间点假手术组(P < 0.05);并且十二指肠转流组的体重、血糖水平均低于同时间点空肠转流组,胰岛素、GLP?1和IGF?1水平均高于同时间点空肠转流组(P < 0.05)。结论:胃肠转流术可以有效治疗糖尿病模型大鼠,且随着小肠转流长度的增加,治疗糖尿病的作用更加明显,其作用机制之一可能为胃肠转流术增加GLP?1和IGF?1的合成与分泌。
英文摘要:
      Objective:To explore the hypoglycemic effect of gastrointestinal bypass and effects on glucagon like peptide ?1(GLP?1)and insulin?like growth factor ?1(IGF?1)levels in diabetic rats. Methods:A total of 60 SD rats were randomly divided into the control group,the sham operation group,the duodenal bypass group,and the jejunal bypass group. The diabetic model was established by injecting of 1% streptozotocin(STZ)intraperitoneally in the sham operation group,the duodenal bypass group and the jejunal bypass group. The surgical operations were performed accordingly. The levels of blood sugar,insulin,serum GLP?1,and IGF?1 were examined before operation and 1,3 and 8 weeks after operation. Results:The survival rates of rats were 100.00% in both the control group and the sham?operated group,and were 93.33% and 86.67% in the duodenal bypass group,and the jejunal bypass group,respectively. The blood glucose,GLP?1 and IGF?1 levels of the sham operation group,the duodenal bypass group,and the jejunal bypass group before operation were significantly higher than those of the control group,and the insulin level was significantly lower than that of the control group(P < 0.05);3 or 8 week after surgery,the body weight,and blood glucose of the duodenal bypass group and the jejunal bypass group were lower than those of the sham operation group at the same time point,and the levels of insulin,GLP?1,and IGF?1 were higher than those of the sham operation group at the same time point(P < 0.05);meanwhile,the body weight,blood glucose of the jejunal bypass group were lower than those of the duodenal bypass group,and the levels of insulin,GLP?1,and IGF?1 were higher than those of the duodenal bypass group(P < 0.05). Conclusion:Gastrointestinal bypass can be effective in the treatment of diabetic rats,and the effect increased with the increase of the length of small intestine. One of the mechanisms may be that gastrointestinal bypass increases the synthesis and secretion of GLP?1 and IGF?1.
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