文章摘要
欧阳巍立,杨 杨,王连生.可溶性生长刺激表达基因2蛋白与急性冠脉综合征患者冠脉病变程度的相关性研究[J].南京医科大学学报,2020,(1):67~71
可溶性生长刺激表达基因2蛋白与急性冠脉综合征患者冠脉病变程度的相关性研究
Correlation between soluble growth stimulator gene 2 protein and severity of coronary artery lesion in patients with acute coronary syndrome
投稿时间:2019-05-26  
DOI:10.7655/NYDXBNS20200113
中文关键词: 急性冠脉综合征  可溶性生长刺激表达基因2蛋白  Gensini评分
英文关键词: acute coronary syndrome  soluble growth stimulator gene 2 protein  Gensini score
基金项目:国家自然科学基金(81770361)
作者单位
欧阳巍立 南京医科大学第一附属医院心血管内科江苏 南京 210029 
杨 杨 南京医科大学第一附属医院心血管内科江苏 南京 210029 
王连生 南京医科大学第一附属医院心血管内科江苏 南京 210029 
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中文摘要:
      目的:探究急性冠脉综合征介入患者血清可溶性生长刺激表达基因2蛋白(soluble growth stimulator gene 2 protein,sST2)的水平及其与冠状动脉病变严重程度的相关性。方法:选取2018年7月1日—12月31日南京医科大学附属第一医院心血管内科住院急性冠脉综合征患者173例,依据急性冠脉综合征急诊快速诊疗指南中的诊断标准分为不稳定型心绞痛(UA)组、急性ST段抬高型心梗(STEMI)组、急性非ST段抬高型心梗(NSTEMI)组。入选同期住院行冠脉造影术结果为阴性的对照组患者共85例。收集所有入选患者甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL?C)、脂蛋白a[LP(a)]、sST2、Killip分级、B型脑尿肽前体(proBNP)、肌钙蛋白T(cTnT)、射血分数(EF)值、左心室舒张末期内径(LVDd)、Gensini评分等临床指标,分析sST2与冠脉狭窄程度Gensini评分、proBNP与Gensini评分的相关性。结果:同对照组相比,UA组sST2水平无明显变化,但STEMI组和NSTEMI组sST2水平显著升高(P<0.01),且STEMI组sST2水平高于NSTEMI组(P<0.05)。同对照组相比,ACS患者Gensini评分较高,其中NSTEMI组高于STEMI组及UA组(P<0.05)。血清sST2水平与Gensini评分呈正相关(r=0.586,P<0.001)。proBNP水平与Gensini评分呈正相关(r=0.680,P<0.001)。结论:血清sST2水平与冠脉病变支数以及冠脉病变复杂程度呈正相关。
英文摘要:
      Objective:To investigate the level of serum soluble growth stimulating gene 2 protein(sST2)and its correlation with the severity of coronary artery lesion in patients with acute coronary syndrome(ACS) undergoing percutaneous transtuminal coronary intervention(PCI) therapy. Methods:From July 1,2018 to December 31,2018,173 patients with ACS were selected from the Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University. According to the diagnostic criteria in the critical care medicine emergency rapid diagnosis and treatment guide for ACS,they were divided into the unstable angina(UA) group,the acute ST segment elevation myocardial infarction(STEMI) group and the acute non?STEMI (NSTEMI) group. A total of 85 coronary angiography negative patients were enrolled as the control group in the same period. The results of TG,TC,LDL?C,LP(a),sST2,Killip classification were collected,and the correlations between sST2 and Gensini score,proBNP and Gensini score were analyzed. Results:Compared with the control group,sST2 level in the UA group has no significant difference,but they were increased significantly in the STEMI group and the NSTEMI group. Moreover,sST2 level in the STEMI group was higher than that in the NSTEMI group. Compared with the control group,Gensini score in the patients with ACS was significantly higher,which in the NSTEMI subgroup was higher than that in the STEMI group and the UA group. Serum sST2 level was correlated with Gensini score significantly(r=0.586,P < 0.001). The proBNP level was correlated with Gensini score significantly(r=0.680,P < 0.001). Conclusion:Serum sST2 level was positively correlated with the number of coronary lesions and the complexity of coronary lesions.
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