文章摘要
尹光丽,李建勇,缪扣荣.造血干细胞移植植入失败的研究进展[J].南京医科大学学报,2020,(1):141~146
造血干细胞移植植入失败的研究进展
Progress on graft failure of allogeneic hematopoietic stem cell transplantation
投稿时间:2018-05-27  
DOI:10.7655/NYDXBNS20200129
中文关键词: 造血干细胞  植入失败  免疫介导  供者淋巴输注
英文关键词: hematopoietic stem cell  graft failure  immune mediated  donor lymphocyte infusion
基金项目:国家自然科学基金面上项目(81470329)
作者单位
尹光丽 南京医科大学第一附属医院血液科江苏 南京 210029 
李建勇 南京医科大学第一附属医院血液科江苏 南京 210029 
缪扣荣 南京医科大学第一附属医院血液科江苏 南京 210029 
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中文摘要:
      造血干细胞移植是治疗造血系统恶性肿瘤及某些遗传性疾病的重要手段,其中造血及免疫功能重建是移植取得成功的基础。植入失败是造血干细胞移植取得成功的一个主要障碍,并且严重危及患者的短期生存。随着人类白细胞抗原不相合或半相合移植及减低剂量预处理技术越来越广泛的应用,植入失败的发生率也随之增加。对植入失败发病机制的深入研究和更大数据的临床分析,发现并鉴定植入失败的重要预测指标,可帮助我们早期预防这一重要并发症的发生。文章拟对造血干细胞移植植入失败的概念、发病机制、相关影响因素及治疗手段等方面的最新进展作一综述。
英文摘要:
      Hematopoietic stem cell transplantation(HSCT)is an important method to treat hematopoietic malignancies and some inherited diseases. Hematopoietic and immunological reconstitutions are the basis of successful transplantation. One significant obstacle to the success of HSCT is represented by graft failure,which severely endangers patients’ short?term survival. As human leukocyte antigen mismatched or haploidentical transplantation,and reduced intensity conditioning technology are more and more widely carried out,the incidence of implant failure increasing. With the study of the mechanism of implant failure and the clinical analysis of larger data,identifying important predictors of implant failure can help us to prevent this important complication of hematopoietic stem cell transplantation early. Here,we provide an overview on the recent advances in the concept,pathogenesis,related factors and treatment methods of hematopoietic stem cell engraftment failure.
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