文章摘要
马红霞.多基因风险评分在恶性肿瘤风险预测中的应用展望[J].南京医科大学学报,2020,(4):467~469
多基因风险评分在恶性肿瘤风险预测中的应用展望
Application of polygenic risk scores in the risk prediction of cancer
投稿时间:2020-02-23  
DOI:10.7655/NYDXBNS20200401
中文关键词: 多基因风险评分  全基因组关联研究  恶性肿瘤  风险预测
英文关键词: polygenic risk score  genome⁃wide association study  cancer  risk prediction
基金项目:国家自然科学基金(81922061,81973123)
作者单位
马红霞 南京医科大学公共卫生学院流行病学系江苏 南京 211166 
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中文摘要:
      多基因风险评分通过综合多个易感位点的累积效应预测个体的肿瘤发病风险,对肿瘤高危人群的筛查和有效防治具有应用价值。近年来,多基因风险评分的构建方法和应用范畴得到了进一步拓展和完善。本文就多基因风险评分应用于恶性肿瘤风险预测的最新进展进行简要介绍,总结其应用展望和挑战。
英文摘要:
      Polygenic risk score predicts cancer risk by integrating the effects of multiple susceptibility loci,which has potential application in the screening of high?risk population. In recent years,the construction method and application of polygenic risk score have been further improved and expanded. This paper reviews the most up?to?date advances in the application of polygenic risk score to the risk prediction of cancer,and summarizes the prospects and challenges.
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