文章摘要
蔡兴龙,刘 璇,黄 玲,张永臣.南京地区91例新型冠状病毒肺炎患者首次入院相关实验室检查结果分析[J].南京医科大学学报,2020,(4):478~484
南京地区91例新型冠状病毒肺炎患者首次入院相关实验室检查结果分析
Analysis of related laboratory examination results of 91 patients with coronavirus disease 2019 at first admission in Nanjing area
投稿时间:2020-03-03  
DOI:10.7655/NYDXBNS20200404
中文关键词: 新型冠状病毒肺炎  实验室指标  白细胞  淋巴细胞
英文关键词: coronavirus disease 2019  laboratory index  white blood cell  lymphocyte
基金项目:
作者单位
蔡兴龙 南京市第二医院(南京市公共卫生医疗中心)检验检测中心江苏 南京 210003 
刘 璇 南京市第二医院(南京市公共卫生医疗中心)检验检测中心江苏 南京 210003 
黄 玲 南京市第二医院(南京市公共卫生医疗中心)检验检测中心江苏 南京 210003 
张永臣 南京市第二医院(南京市公共卫生医疗中心)检验检测中心江苏 南京 210003 
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中文摘要:
      目的:回顾性分析新型冠状病毒肺炎(coronavirus disease 2019,COVID?19)患者首次入院的相关实验室指标变化,为临床早期诊治提供实验室参考依据。方法:选取和分析南京市公共卫生医疗中心收治的91例COVID?19患者首次入院时实验室检查指标,包括血液常规、生化指标、炎症标志物、凝血功能和淋巴细胞亚群计数等的分布情况。结果:血液常规检查中部分患者出现白细胞总数和淋巴细胞计数降低,降低患者占比分别为21.98%和17.58%。生化指标检查中丙氨酸氨基转移酶、天门冬氨酸氨基转移酶和乳酸脱氢酶升高的比例分别为13.19%、14.29%和36.67%,在心肌酶检查中磷酸肌酸激酶升高的比例为18.37%(男)、9.75%(女),磷酸肌酸激酶同工酶、肌红蛋白和肌钙蛋白I升高的比例分别为5.68%、6.82%和19.32%。炎症指标检查中降钙素原水平整体变化不大,C?反应蛋白水平升高。凝血功能和纤溶检测中各指标无明显异常。淋巴细胞亚群检测发现CD3+T、CD4+T、CD8+T、CD16/56+NK细胞和CD19+B细胞结果正常比例分别为62.07%、60.92%、65.51%、73.26%和95.35%,降低比例分别为32.18%、34.48%、27.59%、24.42%和4.65%。结论:COVID?19患者首次入院部分实验室指标出现特征性改变,可供临床初步判断,综合评估患者全身情况,结合核酸检测可提供重要参考依据。
英文摘要:
      Objective:To retrospectively analyze the changes of related laboratory indexes at first admission in patients with coronavirus disease 2019(COVID?19),so as to provide laboratory reference for early clinical diagnosis and treatment. Methods:The laboratory examination indexes,including blood routine,biochemical indexes,inflammatory markers,coagulation function,and lymphocyte subsets count were selected and analyzed at first admission in 91 patients with COVID?19 and admitted to Nanjing Public Health Medical Center. Results:The total white blood cells and the lymphocytes counts in the routine blood examination were decreased in 21.98% and 17.58% of patients,respectively. In biochemical indexes,ALT,AST,and LDH were elevated in 13.19%,14.29%,and 36.67% of patients,respectively; the proportions of patients with elevated phosphocreatine kinase in myocardial enzyme examination were 18.37% in male and 9.75% in female,and creatine kinase isoenzyme,myoglobin,and troponin I were elevated in 5.68%,6.82%,and 19.32% of patients,respectively. The level of inflammatory index procalcitonin was generally normal,while the level of C?reactive protein was increased. There were no obvious abnormalities in the indexes of coagulation function and fibrinolysis. The proportions of patients with normal CD3+T,CD4+T,CD8+T,CD16/56+NK cells,and CD19+B cells were 62.07%,60.92%,65.51%,73.26%,and 95.35%,respectively,and reduced in 32.18%,34.48%,27.59%,24.42%,and 4.65% of patients,respectively. Conclusion:Some laboratory indexes of patients with COVID?19 showed characteristic changes at first admission,which can provide preliminary clinical judgment,comprehensive assessment of the patient’s condition,and provide important reference based on nucleic acid detection.
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