文章摘要
张雅文,陈良玉,李媛媛,陈佳娣,孙培莉.症状未完全控制的支气管哮喘患者变应原检测结果分析[J].南京医科大学学报,2020,(4):551~556
症状未完全控制的支气管哮喘患者变应原检测结果分析
Analyses of the detection results of allergens among bronchial asthmatic patients with partly controlled or uncontrolled symptoms
投稿时间:2019-09-09  
DOI:10.7655/NYDXBNS20200416
中文关键词: 支气管哮喘  吸入性变应原  食物性变应原  IgE  IgG
英文关键词: bronchial asthma  inhaled allergen  food allergen  IgE  IgG
基金项目:国家重点研发计划专项(2018YFC1311900);江苏省普通高校研究实践创新计划(SJLX16?0374)
作者单位
张雅文 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029扬州大学附属医院呼吸与危重症医学科江苏 扬州 225001 
陈良玉 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
李媛媛 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
陈佳娣 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
孙培莉 南京医科大学第一附属医院呼吸与危重症医学科江苏 南京 210029 
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中文摘要:
      目的:研究变应原相关性检测在支气管哮喘疾病管理中的价值。方法:选取症状未完全控制的哮喘患者108例,对吸入性变应原sIgE(IsIgE)、食物性变应原sIgE(FsIgE)、食物性变应原sIgG(FsIgG)及总IgE(tIgE)检测的结果及其与合并症的相关性进行分析。结果:哮喘患者各类变应原特异性抗体检测的总阳性率为82.41%,其中IsIgE、FsIgE及FsIgG检测的阳性率分别为58.33%、32.41%、56.48%;哮喘伴变应性鼻炎者IsIgE、FsIgE及FsIgG检测的阳性率分别为73.33%、30.0%、70.0%;哮喘伴特应性皮炎者IsIgE、FsIgE及FsIgG检测的阳性率分别为66.67%、20.0%、73.33%;哮喘伴消化系统症状者IsIgE、FsIgE及FsIgG检测的阳性率分别为48.15%、29.63%、55.56%,各组患者IsIgE、FsIgG检测的阳性率均高于FsIgE,且对于总体哮喘患者、哮喘伴变应性鼻炎者及哮喘伴特应性皮炎者,差异具有统计学意义(P < 0.05)。tIgE阳性患者IsIgE阳性率为69.01%,高于tIgE阴性患者(37.84%),差异具有统计学意义。结论:未完全控制的支气管哮喘患者应进行吸入性变应原及食物性变应原抗体检测。对于伴变应性鼻炎者及特应性皮炎者,推荐行IsIgE及FsIgG检测;对于有消化系统症状者,FsIgE也值得关注;对tIgE≥100 kU/L的患者推荐行IsIgE检测。
英文摘要:
      Objective:To explore the value of detections for allergens in the management of bronchial asthma. Methods:A total of 108 patients,whose asthmatic symptoms were uncontrolled or partly controlled,were enrolled in this study. The results of inhaled allergens?specific immunoglobulin E(sIgE),food allergens?specific immunoglobulin E,food allergens?specific immunoglobulin G(sIgG)and total immunoglobulin E(IgE)among these patients and their relationship with comorbidities were analyzed. Results:In patients with bronchial asthma,the positive rate of all kinds of allergens?specific immunoglobulins is 82.41% and the positive rates of inhaled allergens sIgE,food allergens sIgE,food allergens sIgG are 58.33%,32.41%,and 56.48%,respectively. The positive rates of inhaled allergens sIgE,food allergens sIgE,food allergens sIgG are 73.33%,30.0%,and 70.0% respectively in the asthmatic patients with allergic rhinitis;66.67%,20.0% and 73.33% respectively in the asthmatic patients with atopic dermatitis;and 48.15%,29.63% and 55.56% respectively in the asthmatic patients with gastrointestinal symptoms. The positive rates of inhaled allergens sIgE and food allergens sIgG are higher than that of food allergens sIgE,and the difference between the overall patients and the asthmatic patients with allergic rhinitis or atopic dermatitis is statistically significant(P < 0.05). The positive rate of inhaled allergens sIgE in patients with total IgE≥100 kU/L is 69.01%,higher than those with total IgE<100 kU/L(37.84%),and this difference is statistically significant(P < 0.05). Conclusion:Asthmatic patients with partly controlled or uncontrolled symptoms should be tested for immunoglobulin of inhalation allergens and food allergens. It is recommended that the tests of inhaled allergens sIgE and food allergens sIgG should be taken in asthmatic patients with allergic rhinitis/atopic dermatitis. In the asthmatic patients with gastrointestinal symptoms,food allergens sIgE should be tested too. For the patients with total IgE≥100 kU/L,testing inhaled allergens sIgE is suggested.
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