文章摘要
鲁 明.β⁃arrestin在神经精神疾病中的作用及偏向型配基的应用前景[J].南京医科大学学报,2020,(5):623~626
β⁃arrestin在神经精神疾病中的作用及偏向型配基的应用前景
β⁃arrestin and its biased ligands in neuropsychological diseases
投稿时间:2020-01-13  
DOI:10.7655/NYDXBNS20200501
中文关键词: β⁃arrestin  G蛋白偶联受体  精神分裂症  抑郁症  阿尔茨海默病  帕金森病
英文关键词: β ⁃ arrestin  G protein coupled receptor  schizophrenia  depression  Alzheimer’s disease  Parkinson’s disease
基金项目:
作者单位
鲁 明 南京医科大学药理学系江苏省神经退行性疾病重点实验室江苏 南京 211166 
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中文摘要:
      β?arrestin参与调节大量生理和病理进程,例如心血管和胃肠道系统疾病、肾脏和肺功能异常、炎症和代谢紊乱、骨矿物质稳态维持、生殖和中枢神经系统疾病等。随着对β?arrestin介导的信号通路不断深入地了解,G蛋白耦联受体(G protein?coupled receptors,GPCR)偏爱性信号转导为研发更加高效、安全的高选择性药物提供了全新的思路。近年来G蛋白偏向型或β?arrestin偏向型配体不断涌现,尤其β?arrestin偏向型配体在治疗神经精神疾病中显示出巨大的应用前景。
英文摘要:
      β?arrestin is involved in multiple physiological and pathological processes,such as cardiovascular and gastrointestinal diseases,kidney and lung dysfunction,inflammation and metabolic disorders,bone mineral homeostasis maintenance,reproductive and central nervous system diseases. With the in?depth understanding of β?arrestin mediated pathways,G protein?coupled receptors(GPCR)biased signal transduction gives us an insight into the development of selective drugs with higher efficiency and fewer side effects. In recent years,G protein?biased or β?arrestin?biased ligands have continuously emerged. Especially,β?arrestin?biased ligands have shown great application prospects in treating neuropsychiatric diseases.
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