文章摘要
陈 铁,陈 橼,吴金东,曹广鑫,李怀亮,侯炜晓,张一心,江晓晖.进展期胃癌组织中FOXP1和Ki67的表达及对患者预后的影响[J].南京医科大学学报,2020,(8):1181~1185
进展期胃癌组织中FOXP1和Ki67的表达及对患者预后的影响
The expressions of FOXP1 and Ki67 in advanced gastric cancer and the effects on the prognosis of patients
投稿时间:2019-02-16  
DOI:10.7655/NYDXBNS20200817
中文关键词: 胃癌  叉头框P1  Ki67  无复发生存期
英文关键词: gastric carcinoma  forkhead box P1  Ki67  recurrence⁃free survival
基金项目:南通市医学创新团队(团队22);南通市青年医学重点人才(青年068)
作者单位
陈 铁 南通大学附属肿瘤医院外科江苏 南通 226361 
陈 橼 南通大学附属肿瘤医院外科江苏 南通 226361 
吴金东 南通大学附属肿瘤医院外科江苏 南通 226361 
曹广鑫 南通大学附属肿瘤医院外科江苏 南通 226361 
李怀亮 南通大学研究生院临床医学系江苏 南通 226019 
侯炜晓 南通大学研究生院临床医学系江苏 南通 226019 
张一心 南通大学附属肿瘤医院外科江苏 南通 226361 
江晓晖 南通大学附属肿瘤医院外科江苏 南通 226361 
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中文摘要:
      目的:分析进展期胃癌中叉头框P1(forkhead box P1,FOXP1)的表达与增殖因子Ki67的关系,探讨FOXP1联合Ki67与临床各参数之间的相关性及对预后的影响。方法:采用石蜡切片免疫组化SP法分析胃癌及癌旁组织中FOXP1和Ki67表达,对FOXP1和Ki67表达的相关性进行Pearson相关分析,采用单因素和多因素回归分析两者对患者预后的影响。结果:FOXP1在癌组织中低表达,FOXP1和Ki67蛋白的表达在胃癌组织中呈负相关。Ki67高表达和FOXP1低表达是进展期胃癌患者无复发生存期的影响因素。结论:Ki67和FOXP1在进展期胃癌组织中的表达呈负相关,二者共同影响胃癌患者预后。
英文摘要:
      Objective:To analyze the correlation between the expression of forkhead box P1(FOXP1)and proliferative factor Ki67 protein,and investigate the effects on prognosis of advanced gastric carcinoma patients. Methods:Paraffin?embedded sections immunohistochemical SP method was used to detect the expression of FOXP1 and Ki67 in gastric sdenocarcinoma and paracancerous tissue. Pearson rank correlation analysis was used to analyze the relationship,and regression analysis was performed to estimate the effects of FOXP1 and Ki67 expression on the recurrence?free survival(RFS). Results:The expressions of FOXP1 were lower in the gastric cancer tissues than in the corresponding adjacentnon?tumor tissues. There was negative correlation between the expression of FOXP1 and Ki67 in gastric cancer tissue. The results showed that the loss of FOXP1 expression and the higher Ki67 expression were influential factors of efficacy in the RFS. Conclusion:The expression of FOXP1 negatively correlates with the expression of Ki67 in gastric carcinoma. A loss of FOXP1 expression and a higher Ki67 expression affect the prognosis of gastric carcinoma patients together.
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