Objective：To analyze the correlation between the expression of forkhead box P1（FOXP1）and proliferative factor Ki67 protein，and investigate the effects on prognosis of advanced gastric carcinoma patients. Methods：Paraffin-embedded sections immunohistochemical SP method was used to detect the expression of FOXP1 and Ki67 in gastric sdenocarcinoma and paracancerous tissue. Pearson rank correlation analysis was used to analyze the relationship，and regression analysis was performed to estimate the effects of FOXP1 and Ki67 expression on the recurrence-free survival（RFS）. Results：The expressions of FOXP1 were lower in the gastric cancer tissues than in the corresponding adjacentnon-tumor tissues. There was negative correlation between the expression of FOXP1 and Ki67 in gastric cancer tissue. The results showed that the loss of FOXP1 expression and the higher Ki67 expression were influential factors of efficacy in the RFS. Conclusion：The expression of FOXP1 negatively correlates with the expression of Ki67 in gastric carcinoma. A loss of FOXP1 expression and a higher Ki67 expression affect the prognosis of gastric carcinoma patients together.