脂蛋白相关磷脂酶A2水平与糖尿病患者血管内皮功能及动脉弹性的相关性研究
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国家自然科学基金(81100578);高等学校博士学科点专项科研基金(20113234120011)


Association of lipoprotein⁃associated phospholipase A2 levels with vascular endothelial function and arterial elasticity in type 2 diabetes mellitus
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    摘要:

    目的:探讨2型糖尿病患者脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)水平与血管内皮功能及动脉弹性之间的关系。方法:收集在南京医科大学第一附属医院就诊的163例2型糖尿病患者的病例资料,采用胶乳散射免疫比浊法测定血浆Lp-PLA2水平,运用无创外周动脉张力法测定反应性充血指数(reactive hyperemia index,RHI)以评估血管内皮功能,通过脉搏波传导速度(pulse wave velocity,PWV)测定动脉弹性,分析Lp-PLA2水平与血管内皮功能及动脉弹性之间的相关性。结果:在2型糖尿病患者中,伴随Lp-PLA2水平升高,RHI逐渐降低(r=-0.23,P<0.01),而Lp-PLA2与PWV之间则无明显相关性(r=0.13,P=0.17)。进一步多元线性回归分析发现,校正了年龄、性别、低密度脂蛋白胆固醇、糖化血红蛋白、吸烟及体重指数等因素后,Lp-PLA2依然是RHI的独立相关因素(β=-0.231,P=0.027)。结论:血浆Lp-PLA2水平检测有望成为评估2型糖尿病患者血管内皮功能的可靠手段。

    Abstract:

    Objective:To investigate the relationship between lipoprotein-associated phospholipase A2(Lp-PLA2)levels and vascular endothelial function and arterial elasticity in type 2 diabetes mellitus(T2DM)patients. Methods:A total of 163 individuals with T2DM who were admitted to the First Affiliated Hospital of Nanjing Medical University were enrolled. Latex scattering immunoturbidimetric assay was used to determine plasma Lp-PLA2 levels. Noninvasive peripheral arterial tone measurement(PAT)was performed to evaluated endothelial function by reative hyperemia index(RHI),and pulse wave velocity(PWV)were used to determine the arterial elasticity. Results:In T2DM patients,the vascular endothelial function index(RHI)gradually decreased with the increase of LP-PLA2 level(r=-0.23,P<0.01),whereas there is no significant correlation between Lp-PLA2 and PWV(r=0.13,P=0.17). Further multiple linear regression analysis showed that Lp-PLA2 remained as an independent factor for RHI after adjusting for age,gender,LDL-cholesterol,glycosylated hemoglobin,smoking,and body mass index(β=-0.231,P=0.027). Conclusion:Plasma Lp-PLA2 may be a suitable surrogate marker for evaluation of vascular endothelial function.

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崔焕焕,范红旗.脂蛋白相关磷脂酶A2水平与糖尿病患者血管内皮功能及动脉弹性的相关性研究[J].南京医科大学学报(自然科学版),2020,(10):1504-1509

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  • 收稿日期:2019-07-12
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  • 在线发布日期: 2020-11-10
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