文章摘要
田智丹,常立功,王 粮,赵有财.ROSE在肺部病变活检病理诊断中的价值[J].南京医科大学学报,2020,(11):1623~1627
ROSE在肺部病变活检病理诊断中的价值
The value of ROSE in pathological diagnosis of the pulmonary biopsy
投稿时间:2020-06-07  
DOI:10.7655/NYDXBNS20201109
中文关键词: 细胞学现场快速评估  经支气管镜肺活检  超声引导下经支气管针吸活检  细胞学
英文关键词: rapid on⁃site evaluation  TBLB  EBUS⁃TBNA  cytology
基金项目:南京市医学科技发展项目(YKK18098)
作者单位
田智丹 南京医科大学附属南京医院病理科江苏 南京 210006 
常立功 南京医科大学附属南京医院病理科江苏 南京 210006 
王 粮 南京医科大学附属南京医院病理科江苏 南京 210006 
赵有财 南京医科大学附属南京医院病理科江苏 南京 210006 
摘要点击次数: 641
全文下载次数: 264
中文摘要:
      目的:探讨经支气管镜肺活检(transbronchial lung biopsy,TBLB)及超声引导下经支气管针吸活检(endobronchial ultrasound?guided transbronchial needle aspiration,EBUS?TBNA)联合细胞学现场快速评估(rapid on?site evaluation,ROSE)在肺恶性肿瘤细胞学诊断中的应用价值。方法:收集2018年1月—2019年8月在南京市第一医院进行的TBLB和EBUS?TBNA的患者174例,根据有无进行ROSE,分为两组,ROSE组106例,非ROSE组68例。以组织学病理结果为金标准,分析两种方法对肺恶性肿瘤细胞学诊断的灵敏度,并评估两种方法对肺恶性肿瘤的细胞学诊断价值是否有差异。结果:ROSE组和非ROSE组的总确诊率分别为88.7%和77.9%,诊断肺部恶性肿瘤的灵敏度分别为90.1%和71.4%,ROSE组的总确诊率及恶性肿瘤诊断灵敏度高于非ROSE组,两组之间差异有统计学意义(P<0.05)。ROSE组二次检查率小于非ROSE组,两组之间差异有统计学意义(P<0.05)。ROSE组的活检时间大于非ROSE组,出血发生率小于非ROSE组,但差异均无统计学意义。ROSE组标本满意度(96.2%)高于非ROSE组(86.8%),两组之间差异有统计学意义(P<0.05)。结论:联合ROSE可提高TBLB和EBUS?TBNA在取样过程中的标本满意度,提高肺部病变的确诊率,尤其是提高恶性肿瘤细胞学诊断的灵敏度,在肺肿瘤诊断中有一定应用价值。
英文摘要:
      Objective:This study aims to assess the utility of rapid on?site evaluation(ROSE) for transbronchial lung biopsy(TBLB)and endobronchial ultrasound?guided transbronchial needle aspiration(EBUS?TBNA) in cytological diagnosis of lung malignant tumor. Methods:Total 174 cases performed TBLB and EBUS?TBNA procedures prospectively collected between January 2018 to August 2019 at the Affiliated Nanjing Hospital of Nanjing Medical University. They were randomly divided into the two groups according to with or without ROSE. There were 106 cases in ROSE group,while there were 68 cases in non?ROSE group. Histological findings was the gold standard. The accuracy of TBLB or EBUS?TBNA with and without ROSE was compared. The sensitivity of the two methods in cytological diagnosis of lung malignant tumor was analyzed,and the differences between the two methods in cytological diagnosis of lung malignant tumor was compared. Results:Overall accuracy in ROSE group and non?ROSE group was 88.7%和77.9%,respectively. Sensitivity to detect malignant lesions in ROSE group and non?ROSE group was 90.1%和71.4%,respectively. The diagnostic accuracy rate and sensitivity rate in ROSE group were higher than those in non?ROSE group(P<0.05),and the rate of secondary inspection in ROSE group was lower than that in non?ROSE group(P<0.05). The time of inspection in ROSE group was higher than that in non?ROSE group,but there were no siginificant differences between two groups. Specimen satisfaction(96.2%) of ROSE group was higher than that of non?ROSE group(86.8%),and there were significant differences between two groups(P<0.05). Conclusion:The combination of ROSE can improve the satisfaction of TBLB and EBUS?TBNA in the sampling process,improve the diagnostic accuracy rate of lung lesions,especially the sensitivity of cytological diagnosis for malignant tumor,which has certain application value in the diagnosis of lung tumors.
查看全文   查看/发表评论  下载PDF阅读器