文章摘要
张卫杰,张志昱,胡 灿,周 奇,欧阳骏,侯建全,张江磊.代谢综合征与肾透明细胞癌分级和分期相关性的研究[J].南京医科大学学报,2020,(12):1791~1795
代谢综合征与肾透明细胞癌分级和分期相关性的研究
Research on the correlation of metabolic syndrome with tumor grade and stage of clear cell renal carcinoma
投稿时间:2020-04-30  
DOI:10.7655/NYDXBNS20201209
中文关键词: 肾透明细胞癌  代谢综合征  Fuhrman分级  TNM分期
英文关键词: clear cell renal carcinoma  metabolic syndrome  fuhrman grade  TNM stage
基金项目:苏州科技计划项目(SYS2019053);江苏省自然科学基金项目(BK20190175)
作者单位
张卫杰 苏州大学附属第一医院泌尿外科江苏 苏州 215001 
张志昱 苏州大学附属第一医院泌尿外科江苏 苏州 215001 
胡 灿 苏州大学附属第一医院泌尿外科江苏 苏州 215001 
周 奇 苏州大学附属第一医院泌尿外科江苏 苏州 215001 
欧阳骏 苏州大学附属第一医院泌尿外科江苏 苏州 215001 
侯建全 苏州大学附属第一医院泌尿外科江苏 苏州 215001 
张江磊 苏州大学附属第一医院泌尿外科江苏 苏州 215001 
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中文摘要:
      目的:研究代谢综合征及其各组分与肾脏透明细胞癌分级和分期之间的关系。方法:筛选2018年1月—2019年12月本院收治的153例病理确诊为肾透明细胞癌患者的资料进行回顾性分析,收集年龄、性别、吸烟、饮酒、体重指数、血压、空腹血糖、血脂水平、肿瘤直径、分级及分期等信息。肿瘤分级采用1982年Fuhrman四级分类,将Ⅰ、Ⅱ级合并成高分化组,Ⅲ、Ⅳ级合并成低分化组。根据2010年TNM分期标准,将T1a、T1b期作为低分期组,T2a、T2b期作为高分期组。计量资料比较采用t检验进行统计学分析;计数资料比较使用χ2检验;使用Logistic回归分析寻找独立危险因素。结果:肾透明细胞癌的病理分级和分期与代谢综合征有关(P < 0.05),高血压、糖尿病、高血脂与肾透明细胞癌的病理分级、分期有关(P < 0.05)。多因素Logistic回归分析结果表明,高血压、糖尿病、高血脂是肿瘤病理分级的独立危险因素(P < 0.05),而糖尿病和高血脂是肿瘤分期的独立危险因素(P < 0.05)。结论:肾透明细胞癌合并代谢综合征患者的Fuhrman分级、TNM分期更高。
英文摘要:
      Objective:This study aims to investigate the relationship between metabolic syndrome,its components and Fuhrman grade,TNM stage in clear cell renal cell carcinoma patients. Methods:From January 2018 to December 2019,clinical data of 153 cases in our department was analyzed retrospectively,including age,gender,smoking,drinking,body mass index,hypertension,hyperglycemia,hyperlipidemia,tumor diameter,Fuhrman grade and TNM stage. The pathological grading system used was Fuhrman grading system with grade Ⅰ and Ⅱ accepted as high differentiation,grade Ⅲ and Ⅳ as poor differentiation. In addition,the TNM classification of 2010 was used,with T1a and T1b recognized as low stage,T2a and T2b as high stage. The differences of measurement data were compared through t tests,while the differences of count data was analyzed by Chi?square tests. Moreover,logistic regression analysis was used to find independent risk factors. Results:Metabolic syndrome was significantly associated with histological grade and stage(P < 0.05). Hypertension,hyperglycemia and hyperlipidemia were also related to histological grade and stage(P < 0.05). Multivariate Logistc regression analysis also showed that hypertension,hyperglycemia and hyperlipidemia were associated with tumor pathological grade(P < 0.05),while hyperglycemia and hyperlipidemia were associated with tumor stage(P < 0.05). Conclusion:Patients with metabolic syndrome were found to have significant higher grade and T stage of clear cell renal carcinoma.
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