Objective：This study aims to compare the efficiency of ECG diagnosis with single lead artificial intelligence electrocardiography and with traditional Holter. Methods：A total of 152 patients were randomly selected. After elimination of contraindication，they were required to wear single lead artificial intelligent electrocardiograph and traditional multi-lead electrocardiograph for no less than 22 hours according to the clinical examination requirements. Results：There was no statistical difference between the two groups in the total number of cardiac beats，average heart rate，minimum heart rate，atrial premature beats，ventricular premature beats and atrial tachycardia measured by unpaired t test（P > 0.05）. Conclusion：Single-lead artificial electrocardiograph has the same effect as traditional multi-lead electrocardiograph in the recording and interpretation of heart rate. Single-lead artificial electrocardiograph has advantages of low lost，easy to use，artificial intelligence and so on，and it has important value for screening and diagnosis of arrhythmia.