文章摘要
王 芹,姜 敏,郑 闻,陈敏敏,王 春.南京地区体检人群血尿酸与代谢综合征关系的研究[J].南京医科大学学报,2020,(12):1815~1819
南京地区体检人群血尿酸与代谢综合征关系的研究
The relationship between serum uric acid and metabolic syndromes in adults in Nanjing physical examination population
投稿时间:2020-05-30  
DOI:10.7655/NYDXBNS20201214
中文关键词: 代谢综合征  尿酸  横断面研究
英文关键词: metabolism syndromes  uric acid  cross⁃sectional study
基金项目:南京市科学技术发展重点项目(ZKY 15016)
作者单位
王 芹 南京大学医学院附属南京鼓楼医院老年科江苏 南京 210008 
姜 敏 南京大学医学院附属南京鼓楼医院老年科江苏 南京 210008 
郑 闻 南京大学医学院附属南京鼓楼医院老年科江苏 南京 210008 
陈敏敏 南京大学医学院附属南京鼓楼医院老年科江苏 南京 210008 
王 春 南京大学医学院附属南京鼓楼医院老年科江苏 南京 210008 
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中文摘要:
      目的:分析南京地区体检人群中血尿酸(uric acid,UA)与代谢综合征(metabolic syndrome,MS)的关系。方法:纳入2012—2016年年龄在20~70岁共58 207例参加体检的人群,其中男41 707例,女16 500例,MS采用美国国家胆固醇教育成人治疗组第三次指南定义,发生MS危险比值比(OR)采用多因素Logistic回归分析,UA与各指标之间的关系采用多元线性回归分析。结果:随着UA水平的增加,健康人群的低密度脂蛋白胆固醇、腰围、体重指数、血压、空腹血糖、甘油三酯、总胆固醇随之升高(P < 0.01)。MS 组分由0个增加至4或5个,UA水平逐渐升高为298.00 μmol/L、312.90 μmol/L、328.70 μmol/L、345.20 μmol/L和360.20 μmol/L(线性趋势P < 0.01)。校正了年龄、性别、腰围、收缩压、舒张压、血糖、高密度脂蛋白胆固醇、甘油三酯等因素后,多因素Logistic回归分析示与最低的UA四分位组(Q1)相比,UA的三、四分位组(Q3,Q4)MS发生的OR分别为1.18(95%CI:1.06~1.31,P < 0.01),1.31(95%CI:1.19~1.44,P < 0.01);多元线性回归分析显示,血UA与腰围、体重指数、甘油三酯、低密度脂蛋白胆固醇水平呈独立正相关。应用受试者工作曲线(ROC)诊断MS的UA最佳截断点为346.5 μmol /L,灵敏度和特异度分别为 59.7%和62.6%。结论:健康检查人群中MS组分数目与UA水平有相关性,高 UA 水平是影响 MS 发生的相关因素。
英文摘要:
      Objective:This study aims to explore the relationship between serum uric acid(UA)level as a marker of metabolic syndromes(MS)in physical examination adults. Methods:A total of 58 207(41 707 males and 16 500 females)aged 20~70 years were included who received physical examination in Nanjing from 2012?2016. MS were defined according to the criteria of the Adult Treatment Panel Ⅲ. Multivariate logistic regression analysis was used to estimate the odds ratios(OR)of MS,and multiple linear regression analysis was performed to explore the association between UA and characteristic variables. Results:LDL?C,waist,BMI,blood pressure,fasting glucose,triglycerides and cholesterol were increased with quantile UA(P for trend<0.01). UA increased with the rise of MS components from 0 through 4 or 5(298.00 μmol/L,312.90 μmol/L,328.70 μmol/L,345.20 μmol/L and 360.20 μmol/L respectively,P < 0.01 for linear trend). Compared with the first UA quartile(Q1),the multiple logistic regression analysis demonstrated that the risk of MS in those with the third and fourth UA quartiles(Q3,Q4)were 1.18(95%CI:1.06~1.31,P < 0.01)and 1.31(95%CI:1.19~1.44,P < 0.01),respectively. After adjusting for age,sex,waist,systolic blood pressure,diastolic blood pressure,glucose and triglycerides. UA was positively related to waist circumference,body mass index,triglycerides,LDL?C with multiple linear regression analysis. The optimal cutoff point of UA by using receiver operating characteristic(ROC) curve to diagnose MS was 346.5 μmol/L. The sensitivity and specificity were 59.7% and 62.6%,respectively. Conclusion:The component number of MS in health examination population has a certain correlation with the level of UA. Higher UA level is associated with higher incidence of MS.
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