文章摘要
赵佳琳,曹 希,彭 理,王学晶,任新瑜,孙 强.系统性炎症相关指标与乳腺癌临床病理及预后的相关性分析[J].南京医科大学学报,2021,(1):74~81
系统性炎症相关指标与乳腺癌临床病理及预后的相关性分析
Association of systemic inflammation⁃related indicators with clinicopathological factors and prognosis of breast cancer patients
投稿时间:2020-02-21  
DOI:10.7655/NYDXBNS20210114
中文关键词: 乳腺癌  系统性免疫性炎症指数  肿瘤浸润淋巴细胞  程序性死亡受体配体1  预后
英文关键词: breast cancer  systemic immune⁃inflammation index  tumor infiltrating lymphocyte  programmed cell death⁃ligand 1  prognosis
基金项目:北京市科学技术委员会重大专项科技计划(D161100000816005)
作者单位
赵佳琳 中国医学科学院北京协和医学院北京协和医院乳腺外科北京 100730 
曹 希 中国医学科学院北京协和医学院北京协和医院乳腺外科北京 100730 
彭 理 中国医学科学院北京协和医学院北京协和医院乳腺外科北京 100730 
王学晶 中国医学科学院北京协和医学院北京协和医院乳腺外科北京 100730 
任新瑜 中国医学科学院北京协和医学院北京协和医院病理科北京 100730 
孙 强 中国医学科学院北京协和医学院北京协和医院乳腺外科北京 100730 
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中文摘要:
      中国医学科学院北京协和医学院,北京协和医院乳腺外科,北京 100730
英文摘要:
      Objective:To analyze prognostic values of systemic inflammation?related indicators in preoperative peripheral blood of breast cancer patients. Methods:Preoperative inflammatory indexes,such as neutrophil?to?lymphocyte ratio(NLR),platelet?to?lymphocyte ratio(PLR),lymphocyte?to?monocyte ratio(LMR) and systemic immune?inflammation index(SII),were obtained from 380 breast cancer patients who complied with the selection criteria. PD?L1 expressions were detected by immunohistochemistry methods in tumor tissues of 36 triple negative breast cancer(TNBC) patients. The survival analysis was performed based on the rate of breast cancer?related death. Results:Levels of NLR and SII were related to maximum tumor diameter and clinical stage of breast cancer patients,while the PLR and LMR had no significant correlations with clinicopathological features. Univariate and multivariate analysis of survival showed that patients with high SII levels had shorter breast cancer specific survival. Meanwhile,levels of SII were probably correlated with PD?L1 expressions in TNBC patients. Conclusion:Preoperative SII levels could be associated with tumor staging and prognosis in breast cancer patients. There may be a correlation between positive PD?L1 expressions and low SII levels in the TNBC subgroup. Systemic inflammation?related indicators of preoperative peripheral blood may provide further choices for disease surveillance of breast cancer patients.
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