肺高压伴发室上性心律失常危险因素分析
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国家自然科学基金(81273571);江苏高校优势学科建设工程资助项目(JX10231802)


Analysis of risk factors for pulmonary hypertension with supraventricular arrhythmias
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    摘要:

    目的:研究肺高压(pulmonary hypertension,PH)伴发室上性心律失常(supraventricular arrhythmias,SVA)的危险因素,提高对PH伴发SVA的临床认知。方法:回顾性分析2011年1月—2016年12月南京医科大学第一附属医院住院的61例PH患者临床资料,发现14例伴发SVA。将伴发SVA患者纳入SVA组,未发生SVA患者纳入非SVA组,对PH伴发SVA的危险因素进行分析。结果:SVA组共14例,男2例,女12例,年龄(49.21±4.99)岁。非SVA组47例,男8例,女39例,年龄(38.02±1.87)岁。两组比较发现,右心房内径、N末端B型脑利钠肽原(N-terminal pro B-type natriuretic peptide,NT-proBNP)、左心室射血分数、年龄与PH伴发SVA相关(P < 0.05)。Logistic多因素回归分析示,右心房内径与PH伴发SVA显著相关,右心房内径越大PH患者发生SVA可能性越大。截至随访结束,SVA组病死率28.57%,中位生存时间为66个月;非SVA组病死率27.66%,中位生存时间为84个月。结论:右心房内径与PH患者伴发SVA显著相关,是PH患者发生SVA的独立预测因素。

    Abstract:

    Objective:To study the risk factors of pulmonary hypertension(PH)with supraventricular arrhythmias(SVA),and to improve the understanding of PH with SVA. Methods:The clinical data of 61 patients with PH admitted to the First Affiliated Hospital of NMU from January 2011 to December 2016 were retrospectively analyzed,and SVA was observed in 14 cases. Patients with SVA were included in the SVA group. Patients without SVA were included in the non-SVA group. The risk factors of SVA in PH were analyzed. Results:There were 14 patients in the SVA group,2 males and 12 females,with an average age of(49.21 ± 4.988)years. There were 47 patients in the non-SVA group,8 males and 39 females,with an average age of(38.02 ± 1.865)years. There were significant differences in the diameter of right atrium,the N-terminal pro B-type natriuretic peptide(NT-proBNP),ejection fraction of left ventricular,and age between two groups(P < 0.05). Multiple factor analysis suggested that the diameter of the right atrium was significantly related to PH with SVA. At the end of follow-up,the mortality rate in the SVA group was 28.57%,and the median survival time was 66 months;the mortality rate in the non-SVA group was 27.66%,and the median survival time was 84 months. Conclusion:The diameter of right atrium was significantly related to SVA in patients with PH,and was seemed to be an independent predictor of SVA in patients with PH.

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何梦钰,丁怡睿,金琳羚,孔 辉,解卫平.肺高压伴发室上性心律失常危险因素分析[J].南京医科大学学报(自然科学版),2021,(2):207-211

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  • 收稿日期:2020-04-30
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  • 在线发布日期: 2021-03-10
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