文章摘要
Li Yang,Huaijun Zhu,Dongxiao Liu,Song Liang,Hao Xu,Jie Chen,Xuerong Wang,Zekuan Xu.[J].南京医科大学学报,2011,(4):246~253
Aspirin suppresses growth of human gastric carcinoma cell by inhibiting survivin expression
  
DOI:10.7655
中文关键词: 
英文关键词: aspirin, survivin, gastric cancer, apoptosis
基金项目:
作者单位
Li Yang Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Huaijun Zhu Division of Clinical Pharmacy, Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China 
Dongxiao Liu Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Song Liang Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Hao Xu Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Jie Chen Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, China. 
Xuerong Wang Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, China. 
Zekuan Xu Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China 
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中文摘要:
      
英文摘要:
      Regular use of aspirin (ASA) could reduce the risk of gastric cancer although the precise mechanism remains unclear. Down-regulation of survivin may be one of the cyclooxygenase-independent mechanisms whereby ASA induces apoptosis of gastric cancer cell. In this study, we investigated the effect of ASA on the growth, apoptosis and survivin expression of gastric cancer cell line SGC7901. The survival of cells treated with 3.0 and 10.0 mmol/L ASA for 24 h was decreased by 44.6% and 88.5%, respectively. ASA at 3.0 mmol/L inhibited the viability of SGC7901 cells in a time-dependent manner. Apoptosis analysis showed similar results with MTT assay. ASA at 3.0 and 10.0 mmol/L decreased the mRNA transcript levels of survivin and reduced survivin protein levels in SGC7901 cells also in a time-dependent manner. Our findings indicated that ASA inhibited the proliferation of SGC7901 by sup-pressing survivin at both the transcriptional and translational level.
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