文章摘要
Xi Li,Tingzhong Wang,Ke Han,Xiaozhen Zhuo,Qun Lu,Aiqun Ma.[J].南京医科大学学报,2011,(4):274~279
Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure
  
DOI:10.7655
中文关键词: 
英文关键词: heart failure, potassium channel, down-regulation, animal models
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作者单位
Xi Li Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China/Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi 710061, China/Key Laboratory of Envi 
Tingzhong Wang Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China/Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi 710061, China/Key Laboratory of Envi 
Ke Han Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China/Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi 710061, China/Key Laboratory of Envi 
Xiaozhen Zhuo Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China/Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi 710061, China/Key Laboratory of Envi 
Qun Lu Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China/Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi 710061, China/Key Laboratory of Envi 
Aiqun Ma Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China/Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi 710061, China/Key Laboratory of Envi 
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中文摘要:
      
英文摘要:
      Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure (HF). We in-vestigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volume-overload operation followed with pressure-overload. The reversible effect of these changes with bisoprolol was also evaluated. The HF group exhibited left ventricular enlargement, systolic dysfunction, prolongation of cor-rected QT interval (QTc), and increased plasma brain natriuretic peptide levels in the HF rabbits. Several potas-sium channel subunit encoding genes were consistently down-regulated in the HF rabbits. After bisoprolol treat-ment, heart function was improved significantly and QTc was shortened. Additionally, the mRNA expression of potassium channel subunit genes could be partially reversed. The down-regulated expression of potassium channel subunits Kv4.3, Kv1.4, KvLQT1, minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF. Bisoprolol could partially reverse these down-regulations and improve heart function.
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