文章摘要
Shu Chen,Weixue Tang,Shifeng Lou.[J].南京医科大学学报,2006,20(1):
The interaction between cytarabine and vincristine on HL-60 cell line in vitro
  
DOI:10.7655
中文关键词: 
英文关键词: HL-60  median-effect principle  cytarabine  vincristine  combination index(CI)
基金项目:
Shu Chen  Weixue Tang  Shifeng Lou
Department of Hematology,the Second Hospital of Chongqing Medical University, Chongqing 400010, China;Department of Hematology,the Second Hospital of Chongqing Medical University, Chongqing 400010, China;Department of Hematology,the Second Hospital of Chongqing Medical University, Chongqing 400010, China
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中文摘要:
      
英文摘要:
      Objective: To analyze the effect of cytarabine combined with vincristine on HL-60 cell line in vitro. Methods:The median-effect equation and MTT assay were used on HL-60. Results: The cytotoxic activity of cytarabine(Ara-C) and vincristine (VCR) used alone or in combination enhanced as drug concentration increased. The order of administration did not influence the cytotoxic activity of the combined antitumor drugs. The ratio of drug concentration was a factor to influence the killing effect. The interaction of the agents was synergistic at lower concentration, and antagonistic at higher concentration. Conclusion: The combined drugs interaction(CI < 1)was synergistic at lower concentration and antagonistic at higher concentration. The ratio of drug concentration is a significant factor that can influence the killing effect.
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