文章摘要
Xuebing Cao,Yixuan Niu,Yan Xu,Guanglei Yuan,Guirong Wei,Shenggang Sun.[J].南京医科大学学报,2006,20(2):
The role of nerve growth factor inducible protein B in the pathogenesis of levodopa-induced dyskinesias
  
DOI:10.7655
中文关键词: 
英文关键词: levodopa-induced dyskinesias  levodopa  Parkinson's disease  nerve growth factor inducible protein B
基金项目:
Xuebing Cao  Yixuan Niu  Yan Xu  Guanglei Yuan  Guirong Wei  Shenggang Sun
Department of Neurology, Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Neurology, Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Neurology, Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Neurology, Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Neurology, Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Neurology, Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
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中文摘要:
      
英文摘要:
      Objective: To study the role of the expression of nerve growth factor inducible protein B gene (NGFI-B) in striatum in the pathogenesis of levodopa-induced dyskinesias (LID). Methods: The rat model of LID was treated with SCH 23390( 1 mg/kg ip,a dopamine D1 antagonist) and haloperidol (1 mg/kg ip, a dopamine D2 antagonist) respectively. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to measure the expression of NGFI-B mRNA in striatum and the behavior changes were observed. Results: After treatment with SCH23390, abnormal involuntary movement (AIM) in LID rats was decreased ( P <0.05) and the expression of NGFI-B mRNA in striatum did not change significantly. After treatment with haloperidol, the changes of AIM in LID rats were not significant and the expression of NGFI-B mRNA was increased significantly( P < 0.01). Conclusion: LID is associated with over-expression of NGFI-B in striatum. Abnormal activity in the direct pathway and the basal ganglia circuit could be involved in the occurrence of LID.
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