文章摘要
Yongming Zhou,Meixia Yu,Ming Cheng,Liqiong Liu,Jine Zheng,Xiaoqing Li,Hui Zeng,Huiyu Li,Shiang Huang.[J].南京医科大学学报,2006,20(2):
Resistin protein expression in abdominal subcutaneous adipose tissue and placenta in pregnant women
  
DOI:10.7655
中文关键词: 
英文关键词: resistin  pregnant physiological insulin resistance  placenta
基金项目:
Yongming Zhou  Meixia Yu  Ming Cheng  Liqiong Liu  Jine Zheng  Xiaoqing Li  Hui Zeng  Huiyu Li  Shiang Huang
Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China;Department of Gynecology and Obstetrics, Affiliated Hospital of Jiujiang University, Jiujiang,332000, China;Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430030, China;Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China;Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China;Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China;Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China;Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China;Department of Research and Applying Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China
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中文摘要:
      
英文摘要:
      Objective: To explore the expression of resistin protein in abdominal subcutaneous adipose tissue and placental tissue in pregnant women and the relationship between pregnant physiological insulin resistance (IR) and gestational diabetes mellitus(GDM). Methods: The expression of resistin protein in abdominal subcutaneous adipose tissue of pregnant and nonpregnant women and placental tissue was measured using western blotting method. Fasting serum glucose concentration was measured by glucose oxidase assay.Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured. Results: Resistin protein expression in placental tissue(67905 ± 8441)(arbitrary OD units)was much higher than that in abdominal subcutaneous fat tissue in pregnant women (40718 ± 3818)( P <0.01 ) and nonpregnant women (38288 ± 2084) ( P < 0.01 ) respectively, and there was no significant difference in abdominal subcutaneous fat tissue among pregnant and nonpregnant women. Conclusion: Resistin protein expression in placental tissue is much higher than that in abdominal subcutaneous fat tissue in pregnant and nonpregnant women. Resistin protein is secreted from human placental tissue.Resistin is one of the factors which lead to pregnant physiological IR and GDM.
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